Bifunctional peptide having capability to permeate cells and capability to regenerate muscles and use thereof

Patent metadata

Field	Value
Publication number	US-10815312-B2
Application number	US-201916297864-A
Country	US
Kind code	B2
Filing date	Mar 11, 2019
Priority date	Mar 14, 2018
Publication date	Oct 27, 2020
Grant date	Oct 27, 2020

Abstract

Disclosed are a bifunctional peptide having the capability to permeate cells and the capability to regenerate muscles and the use thereof. Advantageously, the bifunctional peptide has a function of regenerating muscle cells and thus is useful for the prevention or treatment of diseases affecting muscle regeneration, and additionally has the capability to permeate cells and thus eliminates the necessity to adhere an additional peptide or add other agent or drug for cell permeation of the peptide, thereby finally exerting an efficient muscle generation effect. Thus, the bifunctional peptide can be easily applied to various surgical regenerative treatments and can shorten the treatment period.

First claim

What is claimed is:

1. A method for treating a muscle disease, comprising administering a bifunctional peptide represented by an amino acid sequence of any one of SEQ ID NOS: 1 to 8, wherein the muscle disease is selected from the group consisting of muscular dystrophy, muscular atrophy, muscular sarcopenia, myositis, polymyositis, peripheral vascular disease, and fibrosis.

2. The method according to claim 1 , wherein the peptide is a bifunctional peptide having a capability to permeate cells and a capability to regenerate muscles.

3. The method according to claim 1 , wherein the peptide facilitates differentiation of stem cells into myocytes.

4. The method according to claim 1 , wherein the peptide is prepared for oral administration, injection or topical implantation.

5. The method according to claim 1 , wherein the peptide is administered at a dose of 0.001 to 1,000 mg per 1 kg of a body weight of a subject in need of treatment.

Assignees

• Seoul Nat Univ R&Db Foundation
• Nano Intelligent Biomedical Eng Corporation Co Ltd

Inventors

• Park Yoon Jeong
• Chung Chong-Pyoung
• Lee Jue-Yeon

Classifications

• A61L27/54 Primary

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61L2430/30

  for muscle reconstruction · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61P21/00

  Drugs for disorders of the muscular or neuromuscular system · CPC title

• C07K7/08 Primary

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title