Process for increasing the stability of a composition comprising polyunsaturated omega-3 fatty acids

Patent metadata

Field	Value
Publication number	US-10798962-B2
Application number	US-201515538825-A
Country	US
Kind code	B2
Filing date	Dec 17, 2015
Priority date	Dec 23, 2014
Publication date	Oct 13, 2020
Grant date	Oct 13, 2020

Abstract

A process for increasing the stability of a composition containing a polyunsaturated omega-3 fatty acid against oxidation proceeds by (i) providing a starting composition containing at least one polyunsaturated omega-3 fatty acid component; (ii) providing a lysine composition; (iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting resulting admixture to spray drying conditions subsequently, thus forming a solid product composition containing at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-3 fatty acid; the product composition exhibiting a solvent content SC selected from the following: SC<5 wt %, SC<3 wt %, SC<1 wt %, or SC<0.5 wt %.

First claim

The invention claimed is:

1. A process for increasing the stability towards oxidation of a composition comprising a polyunsaturated omega-3 fatty acid, said process comprising:
(i) providing a starting composition comprising at least one polyunsaturated omega-3 fatty acid component;
(ii) providing a lysine composition;
(iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting a resulting admixture to spray drying conditions subsequently, thus forming a solid product composition comprising at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-3 fatty acid; the product composition exhibiting a solvent content of less than 5 wt %,
wherein at least 90 wt % of the product composition consists of one or more salts of cations derived from lysine with anions derived from one or more polyunsaturated omega-3 fatty acids and other naturally occurring fatty acids.

2. The process according to claim 1 , wherein lysine composition in (ii) is provided in such a manner that the ratio R=n(ca)/n(lys) of the amount of carboxylic acid functions n(ca) in the starting composition provided in (i) and the amount of lysine n(lys) in the lysine composition provided in (ii) is in a range of 0.9<R<1.1.

3. The process according to claim 1 , wherein the starting composition provided in (i) does not contain more than 5 wt % fatty acid esters.

4. The process according to claim 1 , wherein starting composition in (i) and lysine composition in (ii) are provided in such a manner that at least 95 wt % of the product composition consists of one or more salts of cations derived from lysine with anions derived from one or more polyunsaturated omega-3 fatty acids and other naturally occurring fatty acids.

5. The process according to claim 1 , wherein said starting composition is a food product comprising a polyunsaturated omega-3 fatty acid.

6. The process according to claim 1 , wherein said starting composition is a nutritional product comprising a polyunsaturated omega-3 fatty acid.

7. The process according to claim 1 , wherein said starting composition is a pharmaceutical product comprising a polyunsaturated omega-3 fatty acid.

8. The process according to claim 1 , wherein the product composition has a solvent content of less than 3 wt %.

9. The process according to claim 1 , wherein lysine composition in (ii) is provided in such a manner that the ratio R=n(ca)/n(lys) of the amount of carboxylic acid functions n(ca) in the starting composition provided in (i) and the amount of lysine n(lys) in the lysine composition provided in (ii) is in a range of 0.95<R<1.05.

10. The process according to claim 1 , wherein the starting composition provided in (i) does not contain more than 3 wt % fatty acid esters.

11. The process according to claim 1 , wherein at least 97 wt % of the product composition consists of one or more salts of cations derived from lysine with anions derived from one or more polyunsaturated omega-3 fatty acids and other naturally occurring fatty acids.

12. The process according to claim 1 , wherein increasing the stability towards oxidation of the composition does not comprise microencapsulation.

13. The process according to claim 1 , wherein the product composition is substantially free of antioxidants.

Assignees

• Evonik Operations Gmbh

Inventors

• Knaup Günter
• Latinovic Milan
• Schwarm Michael

Classifications

• C11B5/00

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• A61P35/00

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• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/24

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