Kit of parts for producing a glass ionomer cement, process of production and use thereof

Patent metadata

Field	Value
Publication number	US-10792228-B2
Application number	US-201615775040-A
Country	US
Kind code	B2
Filing date	Oct 11, 2016
Priority date	Nov 11, 2015
Publication date	Oct 6, 2020
Grant date	Oct 6, 2020

Abstract

The invention relates to a kit of parts for preparing a glass ionomer composition for dental use, the kit of parts comprising a Powder Part P and a Liquid Part L, Powder Part P comprising: acid-reactive inorganic filler, Liquid Part L comprising: water, complexing agent, polyacid, either the Powder Part P or the Liquid Part L or the Powder Part P and the Liquid Part L comprising non-aggregated nano-sized particles based on silica or alumina, the composition obtained by combining the components of Powder Part P and Liquid Part L before hardening comprising the components in the following amounts: non-aggregated nano-sized particles: from 0.1 to 15 wt.-%, acid-reactive filler in an amount from 50 to 75 wt.-%, polyacid: 7 to 20 wt.-%, complexing agent: 0.5 to 3 wt.-%, water: 5 to 18 wt.-%, wt.-% with respect to the weight of the whole composition.

First claim

The invention claimed is:

1. A kit of parts for preparing a glass ionomer composition for dental use,
the kit of parts comprising a Powder Part P and a Liquid Part L,
Powder Part P comprising:
acid-reactive inorganic filler,

Liquid Part L comprising:
water,
complexing or chelating agent,
polyacid,

either the Powder Part P or the Liquid Part L or the Powder Part P and the Liquid Part L comprising non-aggregated nano-sized particles based on silica or alumina, the composition obtained by combining the components of Powder Part P and Liquid Part L before hardening comprising the components in the following amounts:
non-aggregated nano-sized particles having a mean particle size in the range of 5 nm to 500 nm from 0.1 to 15 wt.-%,
acid-reactive filler in an amount from 50 to 75 wt.-%,
polyacid: 7 to 20 wt.-%,
complexing agent: 0.5 to 3 wt.-%,
water: 5 to 18 wt.-%,

wt.-% with respect to the weight of the whole composition.

2. The kit of parts of claim 1 , Liquid Part L being characterized by at least one or more of the following parameters:
viscosity: from 1 to 500 Pa*s at 28° C., measured at a shear rate of 1 s −1 ;
density: from 1.1 to 2.0 g/cm 3 ;
pH value of a dispersion of 1 g Liquid Part L and 10 ml water (having an initial pH value of 6) after stirring for 5 min: between 1 and 4.

3. The kit of parts of claim 1 , the ratio of Powder Part P to Liquid Part L being from 4:1 to 1:1 with respect to weight.

4. The kit of parts of claim 1 , the non-aggregated nano-sized particles being characterized by the following feature:
pH value of a dispersion of 1 g nano-sized particles and 10 ml water (having an initial pH value of 6) after stirring for 5 min: between 4 and 7.

5. The kit of parts of claim 1 , the non-aggregated nano-sized particles being further characterized as follows:
being based on silica,
being non surface treated,
being non acid-reactive,
being present in the Liquid Part L only, and/or
being present in an amount of 2 to 10 wt.-% with respect to the weight of the whole composition.

6. The kit of parts of claim 1 , the acid-reactive filler being characterized by at least one or more of the following features:
pH value of a dispersion of 1 g filler and 10 ml water (having an initial pH value of 6) after stirring for 5 min: between 6 and 10;
having a mean particle size in the range of 3 to 10 μm.

7. The kit of parts of claim 1 , the acid reactive filler being selected from basic metal oxides, metal hydroxides, hydroxyapatite, aluminosilicate glasses, fluoroaluminosilicate glasses, glasses having a Si/Al ratio by wt.-% of below 1.5 and mixtures thereof.

8. The kit of parts of claim 1 , the polyacid having a molecular weight (Mw) from 2,000 to 250,000 evaluated against a polyacrylic acid sodium salt standard using gel permeation chromatography.

9. The kit of parts of claim 1 , the complexing or chelating agent being selected from tartaric acid, citric acid, ethylene diamine tetra acetic acid, salicylic acid, mellitic acid, dihydroxy tartaric acid, nitrilotriacetic acid, 2,4 and 2,6 dihydroxybenzoic acid, phosphono carboxylic acids, phosphono succinic acid and mixtures thereof.

10. The kit of parts of claim 1 , not comprising at least one, more or all of the following components:
non-aggregated nano-sized particles based on titania in an amount above 1 wt.-%;
non-aggregated nano-sized particles based on zirconia in an amount above 1 wt.-%;
radically polymerizable component(s) in an amount above 1 wt.-%;
initiator component(s) suitable to cure polymerizable component(s) in an amount above 1 wt.-%;
inhibitor(s) in an amount above 1 wt.-%;
wt.-% with respect to the weight of the whole composition.

11. A composition obtained by combining the components contained in Powder Part P and Liquid Part L of the kit of parts of claim 1 , the composition being characterized by the following parameter before hardening:
Viscosity: less than 10,000 Pa*s at 28° C. measured at a shear rate of 1 s −1 and 90 sec after start of mixing the components of Powder Part P and Liquid Part L.

12. A composition obtained by combining the components contained in Powder Part P and Liquid Part L of the kit of parts of claim 1 , the composition being characterized by at least one, more or all of the following parameters after hardening:
Flexural strength: above 20 MPa determined according to EN-ISO 9917-2:2010;
Compressive strength: above 100 MPa determined according to EN-ISO 9917-1/2007.

13. A dental luting cement, dental filling material, dental core build up material, dental liner or dental root channel filling prepared from the composition of claim 12 .

14. A delivery system comprising Compartment A and Compartment B separated from each other during storage and a nozzle connected to either Compartment A or Compartment B, Compartment A containing Powder Part P and Compartment B containing Liquid Part L, the delivery system having the shape of a dental capsule, wherein Compartment A has a volume in the range of 0.5 to 3 ml and Compartment B has a volume in the range of 0.05 to 1 ml, wherein Powder Part P and Liquid Part L are as defined in claim 1 .

15. A composition obtained by mixing the components of a Powder Part P and a Liquid Part L of claim 1 , wherein the non-aggregated nanoparticles function to reduce the viscosity of the composition.

Assignees

• 3M Innovative Properties Co

Inventors

• Jahns Michael
• Mikulla Markus
• Peez Robert F
• Eckert Adrian S
• Guggenberger Rainer A
• Raynoschek Simone
• Falsafi Afshin
• Craig Bradley D
• Baran Jr Jimmie R
• Oxman Joel D

Classifications

• A61K6/76

  comprising silicon-containing compounds · CPC title

• A61K6/62

  Photochemical radical initiators · CPC title

• A61K6/75

  Apatite · CPC title

• A61K6/77

  Glass · CPC title

• A61K6/71

  Fillers · CPC title