Temperature controlled support surfaces for single use flexible wall systems

Patent metadata

Field	Value
Publication number	US-10774299-B2
Application number	US-201615345590-A
Country	US
Kind code	B2
Filing date	Nov 8, 2016
Priority date	Mar 25, 2008
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

Disclosed is a jacketed, tiered baffle, bioreactor tank comprising an outer cylindrical-shaped jacket and a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket. The outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid.

First claim

What is claimed is:

1. A jacketed, tiered baffle, bioreactor tank, comprising:
an outer cylindrical-shaped jacket; and
a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket, the cylindrical tank having at least one opening configured for alignment with a window or door in the outer cylindrical-shaped jacket, the at least one opening defining a sight window providing a sight path into the chamber;
wherein the outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid,
wherein the tiered baffles define non-linear channels configured to route the heat exchange fluid in a non-linear flow path around the outer tank surface, the non-linear flow path having at least one substantially 90° turn;
wherein the at least one substantially 90° turn is arranged to direct the heat exchange fluid around the sight window to avoid obstruction of the sight path;
wherein the cylindrical tank includes at least one integral baffle forming a protrusion into the chamber such that when the flexible bag is disposed within the chamber, a fluid within the flexible bag is baffled by the at least one baffle; and
wherein the non-linear channels are configured to route the heat exchange fluid around the outer tank surface and into the at least one integral baffle.

2. The jacketed, tiered baffle, bioreactor tank of claim 1 , wherein at least one of the outer cylindrical-shaped jacket and the cylindrical tank comprises a heat conductive material.

3. The jacketed, tiered baffle, bioreactor tank of claim 1 , further comprising a fluid inlet at a bottom of the bioreactor tank and a fluid outlet at a top of the bioreactor tank.

4. The jacketed, tiered baffle, bioreactor tank of claim 1 , wherein the non-linear channels are configured to route the heat exchange fluid around the outer tank surface to provide cooling to about 100% of the outer tank surface.

5. The jacketed, tiered baffle, bioreactor tank of claim 1 , wherein:
the at least one integral baffle is hollow permitting the heat exchange fluid to enter the at least one integral baffle.

6. The jacketed, tiered baffle, bioreactor tank of claim 5 , wherein:
the at least one integral baffle includes a plurality of separator plates disposed vertically along the at least one integral baffle, the plurality of separator plates being configurated to prevent a vertical flow of the heat exchange fluid within the at least one integral baffle from one non-linear channel to another non-linear channel.

7. A jacketed, tiered baffle, bioreactor tank comprising:
an outer jacket; and
a tank disposed axially within the outer jacket, the tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered channels formed by protrusions on the outer tank surface, the tiered channels being configured to route a heat exchange fluid in a non-linear flow path around the outer tank surface;
wherein
the outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid, and
the tank includes at least one integral baffle forming a protrusion into the chamber such that when the flexible bag is disposed within the chamber, a fluid within the flexible bag is baffled by the at least one baffle; and
wherein the tiered channels are configured to route the heat exchange fluid around the outer tank surface and into the at least one integral baffle; and
wherein the tiered channels and the at least one integral baffle are configured such that a flow of the heat exchange fluid into and out of the at least one integral baffle is in a direction generally perpendicular to a central axis of the tank.

8. The jacketed, tiered baffle, bioreactor tank of claim 7 , wherein at least one of the outer jacket and the tank comprises a heat conductive material.

9. The jacketed, tiered baffle, bioreactor tank of claim 7 , wherein the tank includes at least one opening configured for alignment with a window or door in the outer jacket.

10. The jacketed, tiered baffle, bioreactor tank of claim 9 , wherein the at least one opening defines a sight window providing a sight path into the chamber; and
wherein the tiered channels are configured to direct the heat exchange fluid around the sight window to avoid obstruction of the sight path.

11. The jacketed, tiered baffle, bioreactor tank of claim 7 , further comprising a fluid inlet at a bottom of the bioreactor tank and a fluid outlet at a top of the bioreactor tank.

12. The jacketed, tiered baffle, bioreactor tank of claim 7 , wherein the tiered channels are configured to route the heat exchange fluid around the outer tank surface to provide cooling to about 100% of the outer tank surface.

13. The jacketed, tiered baffle, bioreactor tank of claim 7 , wherein:
the at least one integral baffle is hollow permitting the heat exchange fluid to enter the at least one integral baffle.

14. The jacketed, tiered baffle, bioreactor tank of claim 7 , wherein:
the at least one integral baffle includes a plurality of separator plates disposed vertically along the at least one integral baffle, the plurality of separator plates being configurated to prevent a vertical flow of the heat exchange fluid within the at least one integral baffle between the tiered channels.

15. A method for controlling the temperature in a chemical, pharmaceutical or biological reactor system, comprising the steps of:
arranging a cylindrical tank having a chamber within an outer cylindrical-shaped jacket;
disposing a flexible bag within the chamber, the flexible bag being configured to hold a culture fluid;
directing a heat exchange fluid along a non-linear flow path around an outer tank surface of the cylindrical tank to control a temperature of the culture fluid, the non-linear flow path being defined by tiered channels formed by protrusions on the outer tank surface; and
passing the heat exchange fluid from the tiered channels into at least one integral baffle, the at least one integral baffle forming a protrusion into the chamber such that when the flexible bag is disposed within the chamber, the culture fluid within the flexible bag is baffled by the at least one baffle;
wherein passing the heat exchange fluid from the tiered channels into the at least one integral baffle includes directing the heat exchange fluid into the at least one integral baffle in a direction generally perpendicular to a central axis of the cylindrical tank.

16. The method according to claim 15 , wherein the non-linear flow path is defined by tiered channels formed by protrusions on the outer tank surface.

17. The method according to claim 16 , further comprising the step of:
supplying the tiered channels with the heat exchange fluid through a fluid inlet located at a bottom of the outer cylindrical-shaped jacket; and
removing the heat exchange fluid from tiered channels through a fluid outlet located at a top of the outer cylindrical-shaped jacket.

18. The method according to claim 15 , wherein at least one of the outer cylindrical-shaped jacket and the cylindrical tank comprises a heat conductive material.

19

Assignees

• Ge Healthcare Bio Sciences Corp
• Global Life Sciences Solutions Usa Llc

Inventors

• Galliher Parrish M
• Erdenberger Thomas
• Tuohey Colin R
• Crowell Joseph D
• Damren Richard L

Classifications

• B01F35/513

  Flexible receptacles, e.g. bags supported by rigid containers · CPC title

• F28F2013/006

  Heat conductive materials · CPC title

• F28D7/024

  the conduits of only one medium being helically coiled tubes, the coils having a cylindrical configuration · CPC title

• B01J19/18

  Stationary reactors having moving elements inside (B01J19/08, B01J19/26 take precedence) · CPC title

• B01J2219/0009

  Coils · CPC title