Temperature controlling surfaces and support structures

Patent metadata

Field	Value
Publication number	US-10767154-B2
Application number	US-201615098800-A
Country	US
Kind code	B2
Filing date	Apr 14, 2016
Priority date	Mar 25, 2008
Publication date	Sep 8, 2020
Grant date	Sep 8, 2020

Abstract

A heat exchange module for use in a chemical, pharmaceutical or biological reactor system includes a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable reactant container to facilitate heat transfer, a fluid circulation path formed within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated, and at least one baffle protruding from the inner wall of the body into the interior space.

First claim

What is claimed is:

1. A heat exchange module for use in a chemical, pharmaceutical or biological reactor system, comprising:
a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable or single use reactant container to facilitate heat transfer;
a conduit forming a fluid circulation path within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated; and
at least one baffle protruding from the inner wall of the body surrounding the interior space, the at least one baffle protruding into the interior space.

2. The heat exchange module of claim 1 , wherein:
the at least one baffle is a plurality of baffles.

3. The heat exchange module of claim 2 , wherein:
the plurality of baffles have a triangular cross-section.

4. The heat exchange module of claim 3 , wherein:
the plurality baffles extend vertically within the interior space of the body.

5. The heat exchange module of claim 2 , wherein:
the plurality of baffles are hollow such that the heat exchange fluid can be circulated through the baffles; and
wherein at least one baffle of the plurality of baffles provides the thermally conductive surface adapted to contact the replaceable or single use reactant container and facilitate heat transfer.

6. The heat exchange module of claim 5 , wherein:
the at least one thermally conductive surface is a plurality of thermally conductive surfaces; and
at least a portion of the inner wall of the body provides one of the thermally conductive surfaces adapted to contact the replaceable or single use reactant container and facilitate heat transfer.

7. The heat exchange module of claim 6 , wherein:
the portion of the inner wall of the body that provides one of the thermally conductive surfaces is located between two baffles of the plurality of baffles.

8. The heat exchange module of claim 5 , wherein:
the plurality of baffles are integrally formed with the inner wall of the body.

9. The heat exchange module of claim 1 , wherein:
the body is configured to be disposed in a reactor vessel or is integrally formed as part of the reactor vessel.

10. A heat exchange module for use in a chemical, pharmaceutical or biological reactor system, comprising:
a vessel having an inner surface defining a chamber configured for supporting a replaceable or single use reactant container within the chamber, and an outer surface;
a jacket at least partially encompassing the vessel, the jacket and the outer surface of the vessel defining a fluid circulation path therebetween through which a heat exchange fluid can be circulated;
a plurality of baffles protruding from the inner surface of the vessel into the chamber;
at least one of the plurality of baffles is hollow such that the heat exchange fluid can be circulated through the at least one baffle; and
wherein at least one baffle of the plurality of baffles provides a thermally conductive surface adapted to contact the replaceable or single use reactant container to facilitate heat transfer.

11. The heat exchange module of claim 10 , wherein:
the plurality of baffles having a triangular cross-section.

12. The heat exchange module of claim 11 , wherein:
the plurality baffles extend vertically within the interior space of the body.

13. The heat exchange module of claim 10 , wherein:
at least a portion of the inner surface of the vessel provides another thermally conductive surface adapted to contact the replaceable or single use reactant container to facilitate heat transfer.

14. The heat exchange module of claim 10 , wherein:
the replaceable or single use reactant container is a flexible bag.

15. The heat exchange module of claim 10 , wherein:
the plurality of baffles are integrally formed with the inner surface of the vessel.

Assignees

• Ge Healthcare Bio Sciences Corp
• Global Life Sciences Solutions Usa Llc

Inventors

• Damren Richard L
• Erdenberger Thomas
• Tuohey Colin R
• Crowell Joseph D
• Galliher Parrish M
• Clapp Kenneth P
• Mitchell Peter A

Classifications

• B01F35/5312

  with vertical baffles mounted on the walls · CPC title

• B01F33/45

  Magnetic mixers; Mixers with magnetically driven stirrers · CPC title

• B01F35/92

  for heating the outside of the receptacle, e.g. heated jackets or burners · CPC title

• B01F35/513

  Flexible receptacles, e.g. bags supported by rigid containers · CPC title

• B01F2035/98

  Cooling · CPC title