Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter

Patent metadata

Field	Value
Publication number	US-10765604-B2
Application number	US-201716303457-A
Country	US
Kind code	B2
Filing date	May 11, 2017
Priority date	May 24, 2016
Publication date	Sep 8, 2020
Grant date	Sep 8, 2020

Abstract

Dual vial adapter assemblage for use with a drug vial and a liquid vial and including a vented drug vial adapter and a vented liquid vial adapter such that simultaneous venting of the liquid vial and the drug vial assists gravitational flow of liquid contents from the liquid vial into the drug vial for forming liquid drug therein.

First claim

The invention claimed is:

1. A dual vial adapter assemblage for use with a drug vial, a liquid vial and a needleless syringe, the drug vial having a drug vial bottle and a drug vial stopper sealing the drug vial bottle, the drug vial containing a medicament, the liquid vial having a liquid vial bottle and a liquid vial stopper sealing the liquid vial bottle, the liquid vial containing liquid contents for mixing with or reconstituting the medicament in the drug vial to form a liquid drug therein, the needleless syringe being empty, the dual vial adapter assemblage having a longitudinal dual vial adapter assemblage centerline and comprising:
a vented drug vial adapter having a longitudinal drug vial adapter centerline and including a transverse drug vial adapter top wall with an upright drug vial adapter connector, an oppositely directed drug vial adapter skirt for telescopic mounting on the drug vial, and a dual lumen drug vial stopper puncturing cannula for puncturing the drug vial stopper on said telescopic mounting of said vented drug vial adapter on the drug vial, said dual lumen drug vial stopper puncturing cannula having i) a liquid lumen in flow communication with said drug vial adapter connector and ii) a vented air lumen openly vented to the ambient surroundings; and
a vented liquid vial adapter having a longitudinal liquid vial adapter centerline and including a transverse liquid vial adapter top wall with an upright liquid vial adapter connector, an oppositely directed liquid vial adapter skirt for telescopic mounting on the liquid vial, and a dual lumen liquid vial stopper puncturing cannula for puncturing the liquid vial stopper on said telescopic mounting of said vented liquid vial adapter on the liquid vial, said dual lumen liquid vial stopper puncturing cannula having i) a liquid lumen in flow communication with said liquid vial adapter connector and ii) a vented air lumen openly vented to the ambient surroundings,
the vented drug vial adapter and the vented liquid vial adapter being formed as discrete components,
at least one of said dual lumen drug vial stopper puncturing cannula and said dual lumen liquid vial stopper puncturing cannula further comprising a tip located on the longitudinal drug vial adapter centerline or the longitudinal liquid vial adapter centerline,
the arrangement being such that in a set-up position of the dual vial adapter assemblage in which said drug vial adapter connector is connected to, and in flow communication with said liquid vial adapter connector, on initial telescopic mounting of said vented liquid vial adapter on the liquid vial and said vented drug vial adapter on the drug vial, said liquid lumen of said vented drug vial adapter and said liquid lumen of said vented liquid vial adapter collectively define a nonrectilinear fluid flow path from said liquid vial to said drug vial, and subsequent disposing of the liquid vial above the drug vial leads to gravitational flow of liquid contents from the liquid vial to the drug vial for forming the liquid drug therein assisted by simultaneous venting of the liquid vial by drawing ambient air thereinto through said dual lumen liquid vial stopper puncturing cannula's vented air lumen and the drug vial by expelling air therefrom through said dual lumen drug vial stopper puncturing cannula's vented air lumen to the ambient surroundings,
the drug vial adapter being detachable from the liquid vial adapter for providing access to the drug vial adapter connector for enabling connection of the empty needleless syringe thereto for aspiring a liquid drug dosage from the drug vial for administration to a patient.

2. The assemblage according to claim 1 wherein said liquid vial adapter connector is a male connector and said drug vial adapter connector is a female connector for direct sealed engagement with said male connector.

3. A dual vial adapter assemblage for use with a drug vial, a liquid vial and a needleless syringe, the drug vial having a drug vial bottle and a drug vial stopper sealing the drug vial bottle, the drug vial containing a medicament, the liquid vial having a liquid vial bottle and a liquid vial stopper sealing the liquid vial bottle, the liquid vial containing liquid contents for mixing with or reconstituting the medicament in the drug vial to form a liquid drug therein, the needleless syringe being empty, the dual vial adapter assemblage having a longitudinal dual vial adapter assemblage centerline and comprising:
a vented drug vial adapter having a longitudinal drug vial adapter centerline and including a transverse drug vial adapter top wall with an upright drug vial adapter connector, an oppositely directed drug vial adapter skirt for telescopic mounting on the drug vial, and a dual lumen drug vial stopper puncturing cannula for puncturing the drug vial stopper on said telescopic mounting of said vented drug vial adapter on the drug vial, said dual lumen drug vial stopper puncturing cannula having i) a liquid lumen in flow communication with said drug vial adapter connector and ii) a vented air lumen openly vented to the ambient surroundings; and
a vented liquid vial adapter having a longitudinal liquid vial adapter centerline and including a transverse liquid vial adapter top wall with an upright liquid vial adapter connector, an oppositely directed liquid vial adapter skirt for telescopic mounting on the liquid vial, and a dual lumen liquid vial stopper puncturing cannula for puncturing the liquid vial stopper on said telescopic mounting of said vented liquid vial adapter on the liquid vial, said dual lumen liquid vial stopper puncturing cannula having i) a liquid lumen in flow communication with said liquid vial adapter connector and ii) a vented air lumen openly vented to the ambient surroundings,
the vented drug vial adapter and the vented liquid vial adapter being formed as discrete components,
at least one of said dual lumen drug vial stopper puncturing cannula and said dual lumen liquid vial stopper puncturing cannula further comprising a tip located on the longitudinal drug vial adapter centerline or the longitudinal liquid vial adapter centerline,
the arrangement being such that in a set-up position of the dual vial adapter assemblage in which said drug vial adapter connector is connected to, and in flow communication with said liquid vial adapter connector, on initial telescopic mounting of said vented liquid vial adapter on the liquid vial and said vented drug vial adapter on the drug vial, subsequent disposing of the liquid vial above the drug vial leads to gravitational flow of liquid contents from the liquid vial to the drug vial for forming the liquid drug therein assisted by simultaneous venting of the liquid vial by drawing ambient air thereinto through said dual lumen liquid vial stopper puncturing cannula's vented air lumen and the drug vial by expelling air therefrom through said dual lumen drug vial stopper puncturing cannula's vented air lumen to the ambient surroundings,
the drug vial adapter being detachable from the liquid vial adapter for providing access to the drug vial adapter connector for enabling connection of the empty needleless syringe thereto for aspiring a liquid drug dosage from the drug vial for administration to a patient,
wherein each of said liquid vial adapter connector and said drug vial adapter connector is a female connector and the dual vial adapter assemblage further comprises a dual ended liquid transfer coupler having a pair of opposite coupler ends in the form of male connectors for sealed engagement with said liquid vial adapter connector and said drug vial adapter connector in said set-up position.

4. A dual vial adapter assemblage for use with a drug vial, a liquid vial and a needleless syringe, the drug vial having a drug vial bottle and a drug vial stopper sealing the drug vial bottle,

Assignees

• West Pharma Services Il Ltd

Inventors

• Denenburg Igor
• Lev Amir
• David Uri

Classifications

• A61J1/2096 Primary

  Combination of a vial and a syringe for transferring or mixing their contents · CPC title

• A61J1/2089 Primary

  Containers or vials which are to be joined to each other in order to mix their contents (combinations of vial and syringe for mixing their contents A61J1/2096) · CPC title

• A61J1/2082

  for gas filtration · CPC title

• A61J1/2075

  for external venting · CPC title

• A61J1/2048

  Connecting means · CPC title