Parallel mass analysis

Patent metadata

Field	Value
Publication number	US-10755908-B2
Application number	US-201916365623-A
Country	US
Kind code	B2
Filing date	Mar 26, 2019
Priority date	Dec 29, 2006
Publication date	Aug 25, 2020
Grant date	Aug 25, 2020

Abstract

A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.

First claim

The invention claimed is:

1. A mass spectrometer, comprising:
an ion source, arranged to generate ions;
an ion storage device, arranged to receive ions from the ion source and configured to sequentially release first and second samples of ions, the first and second samples of ions respectively having a first and a second range of mass-to-charge ratios, the first and second range of mass-to-charge ratios being different from one another;
a first mass analyser, arranged to receive the first sample of ions from the ion storage device and to analyse the first sample of ions during a first time period; and
a second mass analyser, arranged to receive the second sample of ions and to analyse the second sample of ions during a second time period;
the first and second mass analysers each being selected from a group consisting of: an orbital trap mass analyser, a Fourier Transform-ion cyclotron resonance (FTICR) mass analyser, a multi-reflection time-of-flight mass analyser, and a multi-sector time of flight mass analyser; and
wherein the first and second time periods at least partly overlap.

2. The mass spectrometer of claim 1 , wherein the ion storage device is configured to mass-selectively eject ions of the first range of mass-to-charge ratios so as to provide the first sample of ions and ions of the second range of mass-to-charge ratios so as to provide the second sample of ions.

3. The mass spectrometer of claim 1 , further comprising a mass selection device, located upstream from the ion storage device and configured selectively to transfer ions of the first range of mass-to-charge ratios and ions of the second range of mass-to-charge ratios to the ion storage device.

4. The mass spectrometer of claim 1 , further comprising:
a fragmentation device, arranged to receive ions generated by the ion source and to generate fragment ions; and
wherein the second mass analyser is configured to receive the fragment ions as the second sample of ions.

5. The mass spectrometer of claim 1 , wherein the first mass analyser is configured to analyse the first sample of ions so as to provide a preview scan, the mass spectrometer further comprising:
a controller, configured to control the second mass analyser to terminate analysis of the second sample of ions on the basis of the preview scan.

6. The mass spectrometer of claim 1 , wherein the ion storage device is a first ion storage device, the mass spectrometer further comprising:
a second ion storage device, configured to store received ions; and
wherein the first ion storage device is configured selectively to eject stored ions to the second ion storage device and wherein the second ion storage device is configured to eject stored ions to the second mass analyser so as to provide the second sample of ions.

7. The mass spectrometer of claim 6 , wherein the second ion storage device is a curved trap.

8. The mass spectrometer of claim 1 , wherein the first mass analyser and the second mass analyser are of different types.

9. The mass spectrometer of claim 1 , wherein the first mass analyser and the second mass analyser are of the same type.

10. The mass spectrometer of claim 1 , wherein the first and second mass analysers are integrated into a single construction.

11. The mass spectrometer of claim 1 , further comprising a controller configured to adjust the operation of the second mass analyser based on results obtained from the first mass analyser.

12. The mass spectrometer of claim 1 , wherein the ion storage device has first and second outlets, the first and second outlets being spaced apart from one another, and wherein the ion storage device releases the first sample of ions only through the first outlet and releases the second sample of ions only through the second outlet.

13. The mass spectrometer of claim 1 , wherein the first and second mass analysers are operated at different resolutions.

14. The mass spectrometer of claim 1 , wherein the signals produced by the first and second mass analysers are combined to generate a composite spectrum.

15. The mass spectrometer of claim 1 , wherein the first and second mass analysers share at least one of an injector, a cooler, or an inlet.

16. A method of mass spectrometry, comprising:
generating ions using an ion source;
analysing ions generated using the ion source having a first range of mass-to-charge ratios in a first mass analyser during a first time period;
analysing ions generated using the ion source having a second range of mass-to-charge ratios in a second mass analyser during a second time period;
the first and second mass analysers each being selected from a group consisting of: an orbital trap mass analyser, a Fourier Transform-ion cyclotron resonance (FTICR) mass analyser, a multi-reflection time-of-flight mass analyser, and a multi-sector time of flight mass analyser; and
wherein the first and second time periods at least partly overlap.

17. The method of claim 16 , further comprising storing the ions generated by the ion source prior to analysis.

18. The method of claim 16 , further comprising fragmenting ions generated by the ion source prior to analysis.

19. The method of claim 18 , further comprising a step of mass selecting ions prior to fragmentation.

20. The method of claim 16 , wherein the first and second mass analyser are of different types.

Assignees

• Thermo Fisher Scient (Bremen) Gmbh

Inventors

• Makarov Alexander A
• Horning Stevan R

Classifications

• H01J49/04

  Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components · CPC title

• H01J49/009 Primary

  Spectrometers having multiple channels, parallel analysis · CPC title

• H01J49/425

  with a logarithmic radial electric potential, e.g. orbitraps · CPC title