Biaryl kinase inhibitors
US-10351563-B2 · Jul 16, 2019 · US
US10723734B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10723734-B2 |
| Application number | US-201916443929-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 18, 2019 |
| Priority date | Apr 2, 2014 |
| Publication date | Jul 28, 2020 |
| Grant date | Jul 28, 2020 |
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The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Opening claim text (preview).
The invention claimed is: 1. A method for treating or managing a disease or a disorder mediated by AAK1 activity, the method comprising administering to a patient in need thereof a therapeutically effective amount of (S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine, or a pharmaceutically acceptable salt thereof, wherein a disease or disorder mediated by AAKI activity is Alzheimer's disease.
Ortho-condensed systems · CPC title
directly linked by a ring-member-to-ring-member bond · CPC title
containing only hydrogen and carbon atoms in addition to the ring hetero atom · CPC title
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms · CPC title
Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals · CPC title
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