Biocompatible tubing for liquid chromatography systems
US-9056264-B2 · Jun 16, 2015 · US
US10711927B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10711927-B2 |
| Application number | US-201615124892-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 9, 2016 |
| Priority date | Mar 9, 2015 |
| Publication date | Jul 14, 2020 |
| Grant date | Jul 14, 2020 |
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A ferrule includes a flange and an elongated sleeve extending from the flange. The flange and the elongated sleeve define a bore, which is configured to receive a length of flexible tubing. The elongated sleeve is configured to hold the flexible tubing within the bore via friction. For example, the elongated sleeve is configured to hold the flexible tubing within the bore without compressing the flexible tubing. In this manner, flow through the flexible tubing may be unrestricted. In some embodiments, a distance of flexible tubing contacted by the elongated sleeve is sufficient to hold the flexible tubing within the elongated sleeve without tightly holding or compressing the flexible tubing. This configuration can prevent narrow tubing from becoming blocked and/or the tubing bore can remain smooth (e.g., for accurate mixing, constant fluid flow, and so forth).
Opening claim text (preview).
What is claimed is: 1. A ferrule, comprising: a flange; and an elongated sleeve extending from the flange, the flange and the elongated sleeve defining a bore disposed there through configured to receive a length of flexible tubing, the elongated sleeve configured to hold the length of flexible tubing within the bore via friction, wherein a ratio of a length of the elongated sleeve to an inside diameter of the elongated sleeve ranges from at least approximately ten to at least approximately twenty. 2. The ferrule as recited in claim 1 , wherein the inside diameter of the elongated sleeve is at least approximately sixty-seven one-thousandths of an inch (0.067 in.), and the length of the elongated sleeve is at least approximately ninety-six one-hundredths of an inch (0.96 in.). 3. The ferrule as recited in claim 1 , wherein the ferrule is constructed from a fluoropolymer material. 4. The ferrule as recited in claim 1 , further comprising an internal surface feature to enhance retention of the length of flexible tubing. 5. The ferrule as recited in claim 4 , wherein the internal surface feature comprises at least one of a ridge, an abrasion, or a roughened surface. 6. The ferrule as recited in claim 1 , wherein the flange is configured to be received in a port of a system so that the flange abuts an end surface of the port, the port having a depth, a threaded sidewall, and a fluid passage, the ferrule retained within the port by a threaded nut disposed around the elongated sleeve, wherein the elongated sleeve has a length that is greater than the depth of the port. 7. A fluid connector comprising: a length of flexible tubing; a flange having an insider diameter and a first end surface in a first plane; an elongated sleeve extending from the flange, the elongated sleeve having an inside diameter greater than the inside diameter of the flange, the flange and the elongated sleeve defining a second end surface opposite the first end surface and between the inside diameter of the flange and the inside diameter of the elongated sleeve in a second plane spaced apart from the first plane, the flange and the elongated sleeve defining a bore disposed there through configured to receive the length of flexible tubing to abut the flange at the second end surface opposite the first end surface, the elongated sleeve configured to hold the length of flexible tubing within the bore via friction and allow the flange to be compressed between the first plane and the second plane without compressing the length of flexible tubing; a port having a depth, a threaded sidewall, and a fluid passage, wherein the flange is configured to be received in the port so that the flange abuts an end surface of the port; and a threaded nut disposed around the elongated sleeve for retaining the ferrule within the port, wherein the elongated sleeve has a length that is greater than the depth of the port. 8. The fluid connector as recited in claim 7 , wherein a ratio of a length of the elongated sleeve to an inside diameter of the elongated sleeve ranges from at least approximately ten to at least approximately twenty. 9. The fluid connector as recited in claim 7 , wherein the elongated sleeve has an inside diameter of at least approximately sixty-seven one-thousandths of an inch (0.067 in.) and a length of at least approximately ninety-six one-hundredths of an inch (0.96 in.). 10. The fluid connector as recited in claim 7 , wherein the elongated sleeve and the flange are constructed from a fluoropolymer material. 11. The fluid connector as recited in claim 7 , wherein the elongated sleeve has an internal surface feature to enhance retention of the length of flexible tubing. 12. The fluid connector as recited in claim 11 , wherein the internal surface feature comprises at least one of a ridge, an abrasion, or a roughened surface. 13. A ferrule, comprising: a flange having an insider diameter and a first end surface in a first plane; and an elongated sleeve extending from the flange, the elongated sleeve having an insider diameter greater than the inside diameter of the flange, the flange and the elongated sleeve defining a second end surface opposite the first end surface and between the inside diameter of the flange and the inside diameter of the elongated sleeve in a second plane spaced apart from the first plane, the flange and the elongated sleeve defining a bore disposed there through configured to receive a length of flexible tubing to abut the flange at the second end surface opposite the first end surface, the elongated sleeve configured to hold the length of flexible tubing within the bore via friction and allow the flange to be compressed between the first plane and the second plane without compressing the length of flexible tubing. 14. The ferrule as recited in claim 13 , wherein a ratio of a length of the elongated sleeve to an inside diameter of the elongated sleeve ranges from at least approximately ten to at least approximately twenty. 15. The ferrule as recited in claim 13 , wherein the ferrule is constructed from a fluoropolymer material. 16. The ferrule as recited in claim 13 , further comprising an internal surface feature to enhance retention of the length of flexible tubing. 17. The ferrule as recited in claim 16 , wherein the internal surface feature comprises at least one of a ridge, an abrasion, or a roughened surface. 18. The ferrule as recited in claim 13 , wherein the flange is configured to be received in a port of a system so that the flange abuts an end surface of the port, the port having a depth, a threaded sidewall, and a fluid passage, the ferrule retained within the port by a threaded nut disposed around the elongated sleeve, wherein the elongated sleeve has a length that is greater than the depth of the port.
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