Biocompatible tubing for liquid chromatography systems

Patent metadata

Field	Value
Publication number	US-9056264-B2
Application number	US-201113206873-A
Country	US
Kind code	B2
Filing date	Aug 10, 2011
Priority date	Jul 16, 2010
Publication date	Jun 16, 2015
Grant date	Jun 16, 2015

Abstract

A biocompatible tube that can be used in a liquid chromatography system is described. The tube can have flanged or straight ends, and can be used in conjunction with one or more fitting, assembly.

First claim

We claim:

1. A tube for use in a liquid chromatography system, comprising:
a) an outer layer having an inner surface and an outer surface, and having a first and a second end, wherein at least one of said first and second ends of said outer layer comprises a tip portion and a retention feature for retaining said tip portion, wherein said tip portion comprises a polymer and wherein said retention feature is a barb, an undercut, one or more cross-drilled hole, a reverse taper or a flange; and
b) a biocompatible inner layer having an inner surface, an outer surface, a first end, a second end and a passageway therethrough, wherein said inner layer is located within said outer layer.

2. The tube according to claim 1 , wherein said first end of said outer layer comprises a first tip portion and a first retention feature, and said second end of said outer layer comprises a second tip portion and a second retention feature, wherein said first and second tip portions comprise a polymer.

3. The tube according to claim 1 , wherein said outer layer is comprised of metal.

4. The tube according to claim 1 , wherein said biocompatible inner layer comprises polyetheretherketone (PEEK).

5. The tube according to claim 1 , wherein at least a portion of said inner surface of said outer layer interacts with at least a portion of said outer surface of said inner layer.

6. The tube according to claim 5 , wherein said interaction is friction-based.

7. The tube according to claim 1 , wherein said tip portion comprises PEEK.

8. The tube according to claim 1 , further comprising at least a first fitting assembly.

9. The tube according to claim 8 , further comprising at least a first and a second fitting assembly.

10. The tube according to claim 8 , wherein said fitting assembly comprises:
a) a nut having a first end and a second end, and having a passageway therethrough, wherein said passageway has an internally tapered portion and a lip proximal said second end of said nut, and wherein said second end of said nut has an externally threaded portion;
b) a ferrule having a first externally tapered end and a second end and having a passageway therethrough, wherein said first externally tapered end of said ferrule is adapted to securely engage with said tapered portion of said passageway in said nut; and
c) a ferrule tip having a first externally tapered end, a central portion, and a second externally tapered end, wherein said first externally tapered end and said central portion define a first lip and said second externally tapered end and said central portion define a second lip, and wherein said first end of said ferrule tip is adapted to abut with said second end of said ferrule within said passageway of said nut, and said first lip of said ferrule tip securely engages said lip of said nut.

11. A tube assembly for use in a liquid chromatography system, comprising:
a) a tube comprising:
i) an outer layer having an inner surface and an outer surface, and having a first and a second end, wherein at least one of said first and second ends of said outer layer comprises a tip portion and a retention feature for retaining said tip portion, wherein said tip portion comprises a polymer and wherein said retention feature is a barb, an undercut, one or more cross-drilled hole, a reverse taper or a flange; and
ii) a biocompatible inner layer having an inner surface, an outer surface, a first end, a second end and a passageway therethrough, wherein said inner layer is located within said outer layer; and

b) at least a first fitting assembly associated with said first or second end of said outer layer.

12. The tube assembly according to claim 11 , wherein said first end of said outer layer comprises a first tip portion and a first retention feature, and said second end of said outer layer comprises a second tip portion and a second retention feature, wherein said first and second tip portions comprise a polymer.

13. The tube assembly of claim 12 , wherein said first retention feature is the same as said second retention feature.

14. An analytical instrument system comprising at least one tube assembly comprising:
a) a tube comprising:
i) an outer layer having an inner surface and an outer surface, and having a first and a second end, wherein at least one of said first and second ends of said outer layer comprises a tip portion and a retention feature for retaining said tip portion, wherein said tip portion comprises a polymer and wherein said retention feature is a barb, an undercut, one or more cross-drilled hole, a reverse taper or a flange; and
ii) a biocompatible inner layer having an inner surface, an outer surface, a first end, a second end and a passageway therethrough, wherein said inner layer is located within said outer layer; and

b) at least a first fitting assembly associated with said first or second end of said outer layer, said fitting assembly comprising:
i) a nut having a first end and a second end, and having a passageway therethrough, wherein said passageway has an internally tapered portion and a lip proximal said second end of said nut, and wherein said second end of said nut has an externally threaded portion;
ii) a ferrule having a first externally tapered end and a second end and having a passageway therethrough, wherein said first externally tapered end of said ferrule is adapted to securely engage with said tapered portion of said passageway in said nut; and
iii) a ferrule tip having a first externally tapered end, a central portion, and a second externally tapered end, wherein said first externally tapered end and said central portion define a first lip and said second externally tapered end and said central portion define a second lip, and wherein said first end of said ferrule tip is adapted to abut with said second end of said ferrule within said passageway of said nut, and said first lip of said ferrule tip securely engages said lip of said nut.

15. The system according to claim 14 , wherein said analytical instrument system comprises an ultra high pressure or ultra high performance liquid chromatography system.

Assignees

• Hahn Mark
• Ellis Scott J
• Beemer Eric
• Idex Health & Science Llc

Inventors

• Hahn Mark
• Ellis Scott J
• Beemer Eric

Classifications

• G01N30/6073

  in open tubular form · CPC title

• B01D15/22 Primary

  relating to the construction of the column · CPC title

• G01N30/6039

  in series · CPC title

• G01N30/6004 Primary

  end pieces · CPC title

• G01N30/6026

  Fluid seals · CPC title