Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections

Patent metadata

Field	Value
Publication number	US-10689399-B2
Application number	US-201816017371-A
Country	US
Kind code	B2
Filing date	Jun 25, 2018
Priority date	Dec 21, 2012
Publication date	Jun 23, 2020
Grant date	Jun 23, 2020

Abstract

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):

including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , X, W, Y 1 , Y 2 , Z 1 , and Z 4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

First claim

What is claimed is:

1. A compound having Formula (I):

or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
R 1 is phenyl, substituted with one, two, or three halogens;
Y 1 is hydrogen, C 1-3 alkyl or C 1-3 haloalkyl;
Y 2 is hydrogen, C 1-3 alkyl or C 1-3 haloalkyl;
X is —O—;
W is —CHZ 2 —;
Z 1 and Z 2 , taken together, form -L-;
Z 4 is —CH 2 —;
L is —C(R a ) 2 —C(R a ) 2 —C(R a ) 2 —; and
each R a is independently hydrogen, halogen, hydroxy or C 1-4 alkyl.

2. The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
Y 1 is hydrogen; and
Y 2 is hydrogen.

3. The compound of claim 1 , wherein the compound is selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, and a pharmaceutically acceptable carrier, diluent or excipient.

Assignees

• Gilead Sciences Inc

Inventors

• Bacon Elizabeth M
• Cai Zhenhong R
• Chen Xiaowu
• Cottell Jeromy J
• Desai Manoj C
• Ji Mingzhe
• Jin Haolun
• Lazerwith Scott E
• Mish Michael R
• Morganelli Philip Anthony
• Pyun Hyung-Jung
• Taylor James G
• Trejo Martin Teresa Alejandra

Classifications

• C07D498/14 Primary

  Ortho-condensed systems · CPC title

• A61P31/18

  for HIV · CPC title

• A61K31/5365

  ortho- or peri-condensed with heterocyclic ring systems · CPC title

• C07D471/14 Primary

  Ortho-condensed systems · CPC title

• A61K31/4985 Primary

  Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems · CPC title