Modulators of hemoglobin

Patent metadata

Field	Value
Publication number	US-10683285-B2
Application number	US-201916687474-A
Country	US
Kind code	B2
Filing date	Nov 18, 2019
Priority date	Nov 19, 2018
Publication date	Jun 16, 2020
Grant date	Jun 16, 2020

Abstract

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.

First claim

The invention claimed is:

1. A compound of formula:

or a pharmaceutically acceptable salt of each thereof.

2. A compound of formula:

or a pharmaceutically acceptable salt thereof.

3. A compound of formula:

4. A compound of formula:

or a pharmaceutically acceptable salt thereof.

5. A compound of formula:

6. A compound of formula:

or a pharmaceutically acceptable salt thereof.

7. A compound of formula:

8. A compound of formula:

or a pharmaceutically acceptable salt thereof.

9. A compound of formula:

10. A compound of formula:

or a pharmaceutically acceptable salt thereof.

11. A compound of formula:

12. A compound of formula:

or a pharmaceutically acceptable salt thereof.

13. A compound of formula:

14. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

15. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable excipient.

16. A pharmaceutical composition comprising a compound of claim 5 and a pharmaceutically acceptable excipient.

17. A pharmaceutical composition comprising a compound of claim 7 and a pharmaceutically acceptable excipient.

18. A pharmaceutical composition comprising a compound of claim 9 and a pharmaceutically acceptable excipient.

19. A pharmaceutical composition comprising a compound of claim 11 and a pharmaceutically acceptable excipient.

20. A pharmaceutical composition comprising a compound of claim 13 and a pharmaceutically acceptable excipient.

Assignees

• Global Blood Therapeutics Inc

Inventors

• Li Zhe

Classifications

• C07D403/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D401/06 Primary

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D265/30

  not condensed with other rings · CPC title

• C07D211/22

  by oxygen atoms · CPC title

• A61P7/06

  Antianaemics · CPC title