Suppression of antimicrobial protein levels

Patent metadata

Field	Value
Publication number	US-10675320-B2
Application number	US-201916242095-A
Country	US
Kind code	B2
Filing date	Jan 8, 2019
Priority date	Jan 8, 2018
Publication date	Jun 9, 2020
Grant date	Jun 9, 2020

Abstract

Exercise is a stressor that is known to in some cases suppress antimicrobial protein levels, particularly secretory immunoglobulin type A (IgA). Athletes in the midst of in-season training often demonstrate low levels of sIgA and supplements may enhance post exercise mucosal immune function. A study was conducted where three treatments were administered (botanical spray, botanical drops, placebo) at the onset of 30 minutes of 80% V02 max cycle ergometer exercise. Secretory IgA and Human Alpha Defensin were quantified in saliva samples 30 minutes and 90 minutes post exercise. Analysis revealed a significant treatment effect at 30 min (p=0.030) with post hoc testing revealing a difference between the botanical spray and placebo (p=0.027), but by 90 minutes there was no differences by treatment (p=0.758). Based upon this study, it appears that a single dose of the tested botanical can provide enhanced mucosal immune capability for a short time post exercise.

First claim

We claim:

1. A method for suppressing upper respiratory tract infection comprising:
(a) administrating a dose of a botanical,
(b) wherein the botanical is comprised of Bilberry extract, Noni, Milk Thistle, Echinacea, Goldenseal, Shiitake, White Willow bark, Garlic, Grapeseed extract, Walnut hull and leaf, Raspberry, Fumitory, Gentian, Tea Tree oil, Galbanum oil, Lavender oil, and Oregano oil.

2. The method of claim 1 , wherein the dose of botanical is administered prior to exercise.

3. The method of claim 1 , wherein the dose of botanical is administered during exercise.

4. The method of claim 1 , wherein the dose of botanical is administered after exercise.

5. The method of claim 1 , wherein the dose of botanical is administered by spraying in the oral cavity.

Assignees

• Univ Louisiana At Lafayette

Inventors

• Bellar David
• Aldret Randy

Classifications

• A61K36/45 Primary

  Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry · CPC title

• A61K36/07

  Basidiomycota, e.g. Cryptococcus · CPC title

• A61K36/76

  Salicaceae (Willow family), e.g. poplar · CPC title

• A61K36/74

  Rubiaceae (Madder family) · CPC title

• A61K9/006

  Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays · CPC title