Use of antioxidant-enriched fermented blueberry extracts in the treatment of diabetes

Patent metadata

Field	Value
Publication number	US-9358262-B2
Application number	US-54171409-A
Country	US
Kind code	B2
Filing date	Aug 14, 2009
Priority date	Mar 13, 2003
Publication date	Jun 7, 2016
Grant date	Jun 7, 2016

Abstract

A method of treating or preventing diabetes or obesity that comprises administering an antioxidant-enriched composition produced by fermenting fruit extracts with the bacteria Serratia vaccinii . The antioxidant-enriched composition is capable of decreasing plasma glucose levels, increasing circulating adiponectin levels and decreasing hyperphagia in a subject.

First claim

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. A method of treating diabetes mellitus in a subject comprising orally administering to the subject a therapeutically effective amount of a blueberry juice, a concentrate of blueberry juice, or an extract of blueberry juice that has been fermented with a culture of an isolated bacterial strain having all the identifying characteristics of the bacterium Serratia vaccinii deposited under International Depository Authority of Canada (IDAC) Accession Number 160103, wherein the fermented blueberry juice, concentrate of blueberry juice, or extract of blueberry juice is enriched for phenolic antioxidants and has anti-diabetic activity.

2. The method according to claim 1 , wherein the anti-diabetic activity comprises increasing insulin sensitivity in the subject.

3. The method according to claim 1 , wherein the anti-diabetic activity comprises improving glucose tolerance in the subject.

4. The method according to claim 1 , wherein the anti-diabetic activity comprises decreasing plasma glucose levels in the subject.

5. The method according to claim 1 , wherein the anti-diabetic activity comprises increasing plasma adiponectin levels in the subject.

6. The method according to claim 1 comprising short-term administration of the antioxidant-enriched composition.

7. The method according to claim 1 comprising long-term administration of the antioxidant-enriched composition.

8. The method according to claim 1 , wherein the culture is the culture of the bacterium Serratia vaccinii deposited under International Depository Authority of Canada (IDAC) Accession Number 160103.

9. The method according to claim 1 , wherein the blueberry juice, concentrate of blueberry juice, or extract of blueberry juice is fermented by a process comprising:
(a) providing a sterile medium comprising the blueberry juice, concentrate of blueberry juice, or extract of blueberry juice;
(b) inoculating said sterile medium with the bacterial strain to provide a bacterial culture;
(c) fermenting said bacterial culture to provide a fermented blueberry juice or concentrate of blueberry juice or extract of blueberry juice, and
(d) recovering the fermented blueberry juice or concentrate of blueberry juice or extract of blueberry juice.

10. The method according to claim 9 , wherein said bacterial culture is fermented at a temperature between about 8° C. and about 36° C.

11. The method according to claim 9 , wherein said bacterial culture is fermented under aerobic conditions.

12. The method of claim 1 , wherein a fermented blueberry juice concentrate is administered.

Assignees

• Matar Chantal
• Haddad Pierre S
• Univ Ottawa

Inventors

• Matar Chantal
• Haddad Pierre S

Classifications

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A61K36/87

  Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine · CPC title

• A61K36/45 Primary

  Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry · CPC title