Magnetically actuated articular cartilage regeneration system

Patent metadata

Field	Value
Publication number	US-10668184-B2
Application number	US-201716097714-A
Country	US
Kind code	B2
Filing date	Oct 26, 2017
Priority date	Oct 26, 2016
Publication date	Jun 2, 2020
Grant date	Jun 2, 2020

Abstract

The present invention provides a magnetically-actuated articular cartilage regeneration system for efficiently and nonsurgically regenerating articular cartilage.

First claim

The invention claimed is:

1. A composition for regenerating cartilage comprising a porous microstructure to which at least one magnetic nanoparticle and at least one cartilage-producing cell are attached,
wherein the at least one magnetic nanoparticle is amine-functionalized with a biocompatible material having at least one amine group attached to a surface of the porous microstructure,
wherein the at least one cartilage-producing cell is allowed to settle by cultivation, and
wherein the porous microstructure is made from a biodegradable polymer selected from the group consisting of collagen, hyaluronic acid, gelatin, chitosan, PLGA{poly(lactic-co-glycolic acid)}, PGA{poly(glycolic acid)}, PLA{poly(lactic acid)} and PEG(poyethylene glycol).

2. The composition of claim 1 , wherein the cartilage-producing cell is a cartilage cell or stem cell.

3. The composition of claim 2 , wherein the stem cell is a bone marrow-derived stem cell or fat-derived stem cell.

4. A magnetically-actuated articular cartilage regeneration system, comprising:
a composition for regenerating cartilage of claim 1 ;
an image-photographing unit for imaging the composition for regenerating cartilage and a lesion after irradiating x-ray on a defected area of cartilage; and
a magnetic field forming unit for transporting the composition for regenerating cartilage to the defected area of cartilage.

5. The magnetically-actuated articular cartilage regeneration system of claim 4 , wherein the magnetic field forming unit is a coil or is wearable.

6. The magnetically-actuated articular cartilage regeneration system of claim 5 , wherein the transporting of the composition by the magnetic field forming unit is performed by an electromagnet or a permanent magnet.

7. The magnetically-actuated articular cartilage regeneration system of claim 6 , wherein the permanent magnet is ferrite, neodymium, alnico, samarium cobalt, or a rubber magnet.

8. The magnetically-actuated articular cartilage regeneration system of claim 5 , wherein the cartilage-producing cell is a chondrocyte or a stem cell.

9. The magnetically-actuated articular cartilage regeneration system of claim 8 , wherein the stem cell is a fat-derived stem cell, an umbilical cord blood-derived stem cell or a bone marrow-derived stem cell.

Assignees

• Univ Nat Chonnam Ind Found

Inventors

• Park Suk Ho
• Park Jongoh
• Han Ji Won
• Kang Byung Jeon
• Go Gwangjun

Classifications

• A61L2430/06

  for cartilage reconstruction, e.g. meniscus · CPC title

• A61L27/3817 Primary

  Cartilage-forming cells, e.g. pre-chondrocytes · CPC title

• A61B6/5217

  extracting a diagnostic or physiological parameter from medical diagnostic data · CPC title

• A61K47/6923

  the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb · CPC title

• A61N2/004

  specially adapted for a specific therapy · CPC title