Inducible tissue constructs and uses thereof
US-2024287463-A1 · Aug 29, 2024 · US
Method of three-dimensionally culturing chondrocytes
US9238092B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9238092-B2 |
| Application number | US-201113020498-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 3, 2011 |
| Priority date | Jul 30, 2004 |
| Publication date | Jan 19, 2016 |
| Grant date | Jan 19, 2016 |
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Abstract
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It is intended to provide a method of three-dimensionally culturing normal joint chondrocytes; the production and supply of chondrocytes; and a transplantation material to be used in an injured site in a joint tissue.
First claim
Opening claim text (preview).
The invention claimed is: 1. A composition for regenerating a cartilage tissue, comprising: an amount of isolated collagen and isolated proteoglycan at a ratio of 1:0.51 by weight wherein said ratio is effective to form a three dimensional gelled structure which promotes proliferation of isolated chondrocytes dispersed in said three dimensional gelled structure, wherein the concentration of isolated collagen is 0.8 to 2.4% by weight based on total weight of the composition and the concentration of isolated proteoglycan is 0.4 to 1.2% by weight based on total weight of the composition, and wherein the isolated collagen is selected from the group consisting of atelocollagen and low molecular weight collagen hydrolyzed with enzyme. 2. A kit comprising chondrocytes and a three dimensional gelled structure formed from the composition of claim 1 . 3. A composition for regenerating a cartilage tissue, comprising: an amount of collagen and proteoglycan at a ratio of 1:0.51 by weight, wherein said ratio is effective to form a three dimensional gelled structure which promotes the proliferation of chondrocytes dispersed in said three dimensional gelled structure, wherein the concentration of collagen is 0.8 to 2.4% by weight based on total weight of the composition and the concentration of proteoglycan is 0.4 to 1.2% by weight based on total weight of the composition, and wherein the collagen is selected from the group consisting of atelocollagen and low molecular weight collagen hydrolyzed with enzyme. 4. A composition for regenerating a cartilage tissue, comprising: an amount of isolated collagen and isolated proteoglycan at a ratio of 1:0.51 by weight, and isolated chondrocytes, wherein said ratio is effective to form a three dimensional gelled structure which promotes the proliferation of said chondrocytes dispersed in said three dimensional gelled structure, wherein the isolated collagen is 0.8 to 2.4% by weight and the concentration of isolated proteoglycan is 0.4 to 1.2% by weight, and wherein the isolated collagen is selected from the group consisting of atelocollagen and low molecular weight collagen hydrolyzed with enzyme. 5. The composition of claim 4 , wherein said isolated chondrocytes can be maintained in cultures for several weeks. 6. The composition of claim 4 , wherein said culturing of said chondrocytes form an implantable cartilage tissue. 7. A composition for regenerating a cartilage tissue, comprising: collagen and proteoglycan at a ratio of 1:0.51 by weight, wherein said ratio is effective to form a three dimensional gelled structure which promotes proliferation of isolated chondrocytes dispersed in said three dimensional gelled structure, wherein said three dimensional gelled structure does not contain hyaluronic acid, wherein the concentration of collagen is 0.8 to 2.4% by weight and the concentration of proteoglycan is 0.4 to 1.2% by weight, and wherein the collagen is selected from the group consisting of atelocollagen and low molecular weight collagen hydrolyzed with enzyme.
Assignees
Inventors
Classifications
Drugs for skeletal disorders · CPC title
for joint disorders, e.g. arthritis, arthrosis · CPC title
Chondrocytes; Cartilage · CPC title
Collagen; Gelatin · CPC title
Cartilage, e.g. meniscus · CPC title
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Frequently asked questions
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- What does patent US9238092B2 cover?
- It is intended to provide a method of three-dimensionally culturing normal joint chondrocytes; the production and supply of chondrocytes; and a transplantation material to be used in an injured site in a joint tissue.
- Who is the assignee on this patent?
- Ohshika Shusa, Takagaki Keiichi, Takagaki Yoko, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification A61L27/3895. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 19 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).