Stirred tank reactor systems and methods of use

Patent metadata

Field	Value
Publication number	US-10640741-B2
Application number	US-201615376362-A
Country	US
Kind code	B2
Filing date	Dec 12, 2016
Priority date	Apr 27, 2004
Publication date	May 5, 2020
Grant date	May 5, 2020

Abstract

A reactor system includes a support housing having an interior surface bounding a chamber, the chamber having a vertically extending central longitudinal axis. A flexible bag is disposed within the chamber of the support housing and has an interior surface bounding a compartment. A mixing element is disposed within the compartment of the flexible bag. A drive element, such as a drive shaft, is secured the mixing element, wherein the mixing element is laterally offset from and/or is angled relative to the vertically extending central longitudinal axis of the support housing.

First claim

What is claimed is:

1. A reactor system comprising:
a support housing having an interior surface bounding a chamber, the chamber having a vertically extending central longitudinal axis;
a flexible bag having an interior surface bounding a compartment, the flexible bag being disposed within the chamber of the support housing;
a mixing element disposed within the compartment of the flexible bag; and
a drive shaft having a first end secured to the mixing element within the compartment of the flexible bag and an opposing second end disposed outside of the flexible bag, wherein the mixing element is laterally offset by a distance from the vertically extending central longitudinal axis of the support housing; and
a rotational assembly which includes a casing mounted to the flexible bag and a hub rotatably mounted to the casing, the drive shaft passing through the hub.

2. The reactor system as recited in claim 1 , wherein the mixing element comprises an impeller having an impeller body and a plurality of pitched impeller blades radially outwardly projecting from the impeller body, wherein the mixing element is laterally offset from the vertically extending central longitudinal axis of the support housing so that the impeller body is spaced apart from the vertically extending central longitudinal axis of the support housing.

3. The reactor system as recited in claim 2 , wherein the drive shaft projects into the impeller body.

4. The reactor system as recited in claim 1 , wherein the mixing element comprises an impeller having a rotational axis about which the impeller rotates, wherein the mixing element is laterally offset from the vertically extending central longitudinal axis of the support housing so that the rotational axis is offset from the vertically extending central longitudinal axis of the support housing.

5. The reactor system as recited in claim 4 , wherein the rotational axis is angled relative to the vertically extending central longitudinal axis of the support housing by a defined angle greater than zero.

6. The reactor system as recited in claim 1 , wherein the mixing element is rotatably coupled to the flexible bag.

7. The reactor system as recited in claim 1 , further comprising:
an elongated tubular connector disposed within the compartment of the flexible bag, the tubular connector having a first end connected to the bag and an opposing second end disposed within the compartment;
the mixing element comprising an impeller disposed within the compartment of the flexible bag, the impeller being coupled with the second end of the tubular connector; and
the drive shaft removably received within the tubular connector and removably coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller.

8. The reactor system as recited in claim 7 , further comprising the hub having a passageway extending therethrough, the first end of the tubular connector being secured to the hub.

9. A reactor system comprising:
a support housing having an interior surface bounding a chamber;
a flexible bag having an interior surface bounding a compartment, the flexible bag being disposed within the chamber of the support housing;
an impeller disposed within the compartment of the flexible bag, the impeller having a rotational axis about which the impeller rotates;
a drive shaft secured to the impeller, wherein the rotational axis of the impeller is angled relative to vertical by a defined angle greater than zero; and
a rotational assembly which includes a casing mounted to the flexible bag and a hub rotatably mounted to the casing, the drive shaft extending from the hub to the impeller.

10. The reactor system as recited in claim 9 , wherein the chamber of the support housing has a vertically extending central longitudinal axis, the rotational axis of the impeller being angled relative to the vertically extending central longitudinal axis by the defined angle greater than zero.

11. The reactor system as recited in claim 9 , wherein the impeller is rotatably secured to the flexible bag.

12. The reactor system as claimed in claim 9 , wherein the drive shaft rotates the impeller.

13. The reactor system as recited in claim 9 , wherein the impeller comprises an impeller body and a plurality of pitched impeller blades radially outwardly projecting from the impeller body, the drive shaft projecting into the impeller body.

14. The reactor system as recited in claim 9 , wherein the drive shaft has a central longitudinal axis being disposed at the same angle as the rotational axis.

15. The reactor system as recited in claim 9 , further comprising:
an elongated tubular connector disposed within the compartment of the flexible bag, the tubular connector having a first end connected to the bag and an opposing second end disposed within the compartment;
the impeller being disposed within the compartment of the flexible bag and coupled with the second end of the tubular connector; and
the drive shaft being removably received within the tubular connector and removably coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller.

16. The reactor as recited in claim 15 , further comprising the first end of the tubular connector being secured to the hub.

17. The reactor system as claimed in claim 16 , wherein rotation of the drive shaft facilitates rotation of the impeller, hub, and tubular connector.

18. The reactor system as claimed in claim 15 , wherein the tubular connector comprises a flexible tube.

19. The reactor system as recited in claim 1 , further comprising:
the drive shaft having a central longitudinal axis extending along the length thereof; and
a drive motor coupled to the drive shaft such that activation of the drive motor causes rotation of the drive shaft about the central longitudinal axis of the drive shaft.

20. The reactor system as recited in claim 19 , wherein the drive motor is coupled to the drive shaft such that activation of the drive motor causes rotation of the drive shaft about the central longitudinal axis of the drive shaft without lateral displacement of the drive shaft.

21. The reactor system as recited in claim 9 , wherein the impeller comprises an impeller body and three spaced apart impeller blades radially outwardly projecting from the impeller body.

22. The reactor system as recited in claim 14 , further comprising a drive motor coupled to the drive shaft such that activation of the drive motor causes rotation of the drive shaft about the central longitudinal axis of the drive shaft.

23. The reactor system as recited in claim 14 , further comprising a drive motor, the drive motor being coupled to the drive shaft such that activation of the drive motor causes rotation of the drive shaft about the central longitudinal axis of the drive shaft without lateral displacement of the drive shaft.

Assignees

• Life Technologies Corp
• Baxalta Inc
• Baxalta GmbH

Inventors

• Kunas Kurt T
• Oakley Robert V
• Hasan Fauad F
• Goodwin Michael E
• Larsen Jeremy K
• Jones Nephi D

Classifications

• C12M27/02

  Stirrer or mobile mixing elements · CPC title

• C12M23/28

  disposable or single use · CPC title

• C12M23/14 Primary

  Bags · CPC title

• C12M29/06

  Nozzles; Sprayers; Spargers; Diffusers (per se B01F23/231, B01J19/26) · CPC title

• C12M23/00

  Constructional details, e.g. recesses, hinges (flow directing inserts in C12M27/18-C12M27/24; apparatus for chemical or physical processes in general B01J, chemical or physical laboratory apparatus in general B01L) · CPC title