Stirred tank reactor systems and methods of use

Patent metadata

Field	Value
Publication number	US-9540606-B2
Application number	US-201314109684-A
Country	US
Kind code	B2
Filing date	Dec 17, 2013
Priority date	Apr 27, 2004
Publication date	Jan 10, 2017
Grant date	Jan 10, 2017

Abstract

A method of mixing a fluid includes positioning a flexible bag into the chamber of a support housing, the support housing having a plurality of baffles positioned so that the bag folds around the baffles. A fluid is delivered into a compartment of the flexible bag. A mixing element, such as an impeller, is moved within the compartment of the flexible bag so as to mix the fluid therein.

First claim

What is claimed is:

1. A method of mixing a fluid, the method comprising:
positioning a flexible bag into a chamber of a support housing;
delivering a fluid into a compartment of the flexible bag; and
moving a mixing element within the compartment of the flexible bag so as to mix the fluid therein, the step of moving the mixing element comprising:
removably inserting a drive shaft into a tubular connector having a first end and an opposing second end, the first end of the tubular connector being connected to the bag, the second end of the tubular connector being secured to an impeller disposed within the compartment of the flexible bag; and
rotating the drive shaft so that the impeller rotates relative to the bag.

2. The method as recited in claim 1 , wherein the step of delivering the fluid comprises delivering a culture comprising cells or microorganisms.

3. The method as recited in claim 1 , further comprising the first end of the tubular connected being rotatably secured to the bag so that rotation of the drive shaft facilitates concurrent rotation of the impeller and the tubular connector.

4. The method as recited in claim 3 , further comprising a casing mounted to the flexible bag and a hub rotatably mounted to the casing, the hub having a passageway extending therethrough, the first end of the tubular connector being secured to the hub.

5. The method as recited in claim 4 , wherein the drive shaft engages the hub so that rotation of the drive shaft rotates the hub.

6. The method as recited in claim 1 , further comprising securing an end of the drive shaft to the impeller.

7. A reactor system comprising:
a support housing having an interior surface bounding a chamber;
a flexible bag having an interior surface bounding a compartment, the flexible bag being disposed within the chamber of the support housing;
an elongated tubular connector disposed within the compartment of the flexible bag, the tubular connector having a first end connected to the bag and an opposing second end disposed within the compartment;
a mixing element disposed within the compartment of the flexible bag, the mixing element being coupled with the second end of the tubular connector; and
a drive shaft removably received within the tubular connector such that rotation of the drive shaft facilitates rotation of the mixing element.

8. The reactor as recited in claim 7 , wherein the mixing element comprises an impeller disposed within the compartment of the flexible bag.

9. The reactor as recited in claim 7 , further comprising a rotational assembly which includes a casing mounted to the flexible bag and a hub rotatably mounted to the casing, the hub having a passageway extending therethrough, the first end of the tubular connector being secured to the hub.

10. The reactor system as claimed in claim 9 , wherein the drive shaft engages the hub such that rotation of the drive shaft facilitates rotation of the hub.

11. The reactor system as claimed in claim 9 , wherein rotation of the drive shaft facilitates rotation of the mixing element, hub, and tubular connector.

12. The reactor system as claimed in claim 7 , wherein the tubular connector comprises a flexible tube.

13. The reactor system as recited in claim 7 , wherein the first end of the tubular connector is rotatably coupled with the flexible bag.

14. The reactor system as recited in claim 7 , further comprising:
a housing;
a motor mount disposed on the housing and having a passage extending therethrough; and
a drive motor coupled with the motor mount for selectively rotating the motor mount relative to the housing, the drive shaft being engaged with the motor mount so that rotation of the motor mount by the drive motor facilitates rotation of the drive shaft.

Assignees

• Life Technologies Corp
• Baxalta Inc
• Baxalta GmbH

Inventors

• Kunas Kurt T
• Oakley Robert V
• Hasan Fauad F
• Goodwin Michael E
• Larsen Jeremy K
• Jones Nephi D

Classifications

• C12M23/00

  Constructional details, e.g. recesses, hinges (flow directing inserts in C12M27/18-C12M27/24; apparatus for chemical or physical processes in general B01J, chemical or physical laboratory apparatus in general B01L) · CPC title

• C12M29/06

  Nozzles; Sprayers; Spargers; Diffusers (per se B01F23/231, B01J19/26) · CPC title

• C12M23/14 Primary

  Bags · CPC title

• Y10T29/49826

  Assembling or joining · CPC title

• C12M27/02 Primary

  Stirrer or mobile mixing elements · CPC title