Prophylactic and/or therapeutic agent for NAFLD/NASH

Patent metadata

Field	Value
Publication number	US-10610558-B2
Application number	US-201615776108-A
Country	US
Kind code	B2
Filing date	Nov 25, 2016
Priority date	Nov 27, 2015
Publication date	Apr 7, 2020
Grant date	Apr 7, 2020

Abstract

The present invention provides a prophylactic and/or therapeutic agent for non-alcoholic fatty liver disease (NAFLD), and particularly non-alcoholic steatohepatitis (NASH) comprising an ume (Japanese apricot) juice concentrate or a processed product thereof. The prophylactic and/or therapeutic agent is obtained by utilizing a component contained in a plant or a processed product thereof, and hence is safe and easily taken. It has been confirmed that when the ume juice concentrate or the processed product thereof is orally administered to a streptozocin (STZ)-induced NAFLD model mouse or an STZ-induced NASH model mouse, liver fibrogenesis can be reduced.

First claim

The invention claimed is:

1. A method for treating or lowering the incidence or progression of non-alcohol steatohepatitis (NASH), comprising administering an effective amount of an ume juice concentrate or a processed product thereof to a subject in need of reduction of fibrogenesis in liver tissue.

2. The method according to claim 1 , wherein the processed product of the concentrate is a neutralized processed product of the concentrate.

3. The method according to claim 1 , wherein the concentrate is a heated concentrate.

4. The method according to claim 1 , wherein the ume juice concentrate or the processed product thereof is administered orally.

5. The method according to claim 1 , wherein the ume juice concentrate or the processed product thereof is used as a dietary supplement.

6. The method according to claim 2 , wherein the concentrate is a heated concentrate.

7. The method according to claim 2 , wherein the ume juice concentrate or the processed product thereof is administered orally.

8. The method according to claim 3 , wherein the ume juice concentrate or the processed product thereof is administered orally.

9. The method according to claim 6 , wherein the ume juice concentrate or the processed product thereof is administered orally.

Assignees

• Adabio Co Ltd
• Otsuka Pharma Factory Inc

Inventors

• Hiraishi Katsuya
• Jimma Fumie
• Soma Hiroyuki
• Adachi Taro
• Adachi Masakazu
• Yamaoka Ippei
• Kagawa Tomohiro

Classifications

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L2/385

  Concentrates of non-alcoholic beverages · CPC title

• A61K36/736 Primary

  Prunus, e.g. plum, cherry, peach, apricot or almond · CPC title

• A61P1/16 Primary

  for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title