Therapeutic compounds
US-2019185441-A1 · Jun 20, 2019 · US
Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting
US10604501B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10604501-B2 |
| Application number | US-201716310305-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 13, 2017 |
| Priority date | Jun 15, 2016 |
| Publication date | Mar 31, 2020 |
| Grant date | Mar 31, 2020 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.
First claim
Opening claim text (preview).
We claim: 1. A profluorescent compound having the formula, or an ortho-substituted analogue thereof: wherein R 1 and R 3 are independently H, aryl or alkyl groups, and R 2 is an acyl group or a group chemically modifiable to an acyl group.
Assignees
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Classifications
- C07D311/72Primary
3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols · CPC title
Radicals substituted by oxygen atoms · CPC title
with fluorescent label · CPC title
with the first amino acid being basic · CPC title
with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group · CPC title
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- What does patent US10604501B2 cover?
- The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific deliv…
- Who is the assignee on this patent?
- Univ Arizona State
- What technology area does this patent fall under?
- Primary CPC classification C07D311/72. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 9 related publications on this page (citations in our corpus or others sharing the same primary CPC).