Multifunctional radical quenchers for the treatment of mitochondrial dysfunction

Patent metadata

Field	Value
Publication number	US-9102626-B2
Application number	US-201214009437-A
Country	US
Kind code	B2
Filing date	Apr 4, 2012
Priority date	Apr 4, 2011
Publication date	Aug 11, 2015
Grant date	Aug 11, 2015

Abstract

The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A):

and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

First claim

We claim:

1. A compound of formula:

wherein
X is halogen;
R 1 is hydrogen, C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, —OR 7 , —SR 7 , —NHR 7 , or —N(R 7 ) 2 , each optionally substituted with one to four substituents selected from halogen, —CN, —NO 2 , C 1 -C 6 alkyl, halo(C 1 -C 6 alkyl), —OR 8 , —NR 8 2 , —CO 2 R 8 , —CONR 8 2 , C 3 -…

Assignees

• Hecht Sidney
• Khdour Omar
• Chowdhury Sandipan Roy
• Talukder Poulami
• Univ Arizona

Inventors

• Hecht Sidney
• Khdour Omar
• Chowdhury Sandipan Roy
• Talukder Poulami

Classifications

• A61P43/00

  Human Necessities · mapped topic

• A61P39/06

  Human Necessities · mapped topic

• A61P25/28

  Human Necessities · mapped topic

• A61P25/16

  Human Necessities · mapped topic

• A61P3/00

  Human Necessities · mapped topic