Therapeutic compositions

Patent metadata

Field	Value
Publication number	US-10596187-B2
Application number	US-201415034965-A
Country	US
Kind code	B2
Filing date	Nov 7, 2014
Priority date	Nov 7, 2013
Publication date	Mar 24, 2020
Grant date	Mar 24, 2020

Abstract

Provided herein are compositions, for example: oral rehydration compositions, beverages, food items, methods and uses, which utilise resistant starch to prevent or treat dehydration, including dehydration which is caused by diarrhoea. Beverages, food items and oral rehydration solutions including a resistant starch, which are suitable for aiding in the maintenance and restoration of hydration levels in individuals undertaking physical activities, including sports, are also disclosed.

First claim

The invention claimed is:

1. An oral rehydration composition for addition to water comprising:
a salt composition;
a fermentable acetylated type IV resistant starch in an amount of 35 g/L to 60 g/L that is acetylated to a substitution value of up to and including 2.5%, and has an amylose content of at least 70% w/w;
xanthan gum in an amount of 1 g/L to 3 g/L to suspend the fermentable acetylated type IV resistant starch in water; and
optionally one or more of:
glucose;
water soluble salts of zinc, magnesium or copper;
sodium bicarbonate; and
combinations thereof.

2. The oral rehydration composition according to claim 1 , wherein the salt composition comprises one or more compounds selected from the group consisting of:
sodium chloride;
potassium chloride; and
trisodium citrate (dihydrate).

3. The oral rehydration composition according to claim 1 , wherein the oral rehydration composition comprises water soluble salts of zinc, magnesium or copper, optionally selected from the group consisting of:
zinc acetate;
zinc picolinate;
zinc gluconate;
magnesium chloride;
copper sulphate; and
combinations thereof.

4. An aqueous composition comprising an oral rehydration composition according to claim 1 , and water, wherein the aqueous composition rehydrates an individual affected by dehydration.

5. The aqueous composition according to claim 4 , wherein the dehydration is caused wholly or partially by diarrhoea, or the dehydration is caused by an individual engaging in a physical activity.

6. A method of rehydrating an individual suffering from dehydration, the method comprising a step of administering an effective amount of an oral rehydration composition to the individual, the oral rehydration composition comprising:
water;
a salt composition;
a fermentable acetylated type IV resistant starch in an amount of 35 g/L to 60 g/L that is acetylated to a substitution value of up to and including 2.5%, and has an amylose content of at least 70% w/w;
xanthan gum in an amount of 1 g/L to 3 g/L to suspend the fermentable acetylated type IV resistant starch in water; and
optionally one or more of:
glucose;
water soluble salts of zinc, magnesium or copper;
sodium bicarbonate; or
combinations thereof.

7. The method according to claim 6 , wherein the salt composition comprises one or more compounds selected from the group consisting of:
sodium chloride;
potassium chloride; and
trisodium citrate (dihydrate).

8. The method according to claim 6 , wherein the dehydration is caused wholly or partially by diarrhoea, or the dehydration is caused by the individual engaging in a physical activity.

9. A beverage comprising an oral rehydration composition according to claim 1 that is formulated for an individual to consume before, during or after the individual engages in a physical activity, wherein the beverage is optionally selected from the group consisting of:
a diluted cordial drink;
a milk based beverage;
a smoothie;
a protein shake; and
a breakfast beverage.

10. The beverage according to claim 9 , wherein the beverage is consumed at least 6 hours before the individual engages in the physical activity.

11. The oral rehydration composition of claim 1 , wherein the fermentable acetylated type IV resistant starch is present in an amount of 45 g/L to 55 g/L.

12. The oral rehydration composition of claim 1 , wherein the oral rehydration composition comprises glucose in an amount of 1 g/L to 7.5 g/L.

13. The oral rehydration composition of claim 1 , wherein the oral rehydration composition comprises glucose in an amount of 1 g/L to 5 g/L.

14. The oral rehydration composition of claim 2 , wherein the oral rehydration composition comprises:
sodium chloride;
potassium chloride; and
trisodium citrate (dihydrate).

Assignees

• Univ Yale
• Flinders Univ Of South Australia
• Ramakrishna Balakrishnan Siddartha
• Balakrishnan Siddartha Ramakrishna

Inventors

• Ramakrishna Balakrishnan Siddartha
• Young Graeme Paul
• Brown Ian Lewis
• Binder Henry Joseph

Classifications

• A23L29/284

  Gelatin; Collagen · CPC title

• A23L29/212

  Starch; Modified starch; Starch derivatives, e.g. esters or ethers (containing starch hydrolysates, e.g. dextrin, A23L29/30) · CPC title

• A23L29/27

  Xanthan not combined with other microbial gums · CPC title

• A23L33/21

  Addition of substantially indigestible substances, e.g. dietary fibres · CPC title

• A23L29/256

  from seaweeds, e.g. alginates, agar or carrageenan · CPC title