Method and apparatus for reducing scattered light in broad-line fundus imaging

Patent metadata

Field	Value
Publication number	US-10582852-B2
Application number	US-201615548393-A
Country	US
Kind code	B2
Filing date	Feb 3, 2016
Priority date	Feb 5, 2015
Publication date	Mar 10, 2020
Grant date	Mar 10, 2020

Abstract

Methods and apparatuses for fundus imaging are presented that use sequential selective illumination patterns to suppress unwanted reflections, scattering and haze from various optical components of a fundus-viewing instrument. This is particularly the case with those unwanted reflections produced by the objective lens contained within said instrument.

First claim

The invention claimed is:

1. A fundus imager for imaging an eye of a subject, comprising:
a source of light for illuminating the retina through the pupil of the eye;
a plurality of illumination regions at the pupil for light entering the eye;
a single collection region at the pupil for returning light exiting the eye, wherein returning light due to multiple of said illumination regions is collected through said single collection region;
a detector for collecting light returning from the eye and generating signals in response thereto;
a processor for generating an image of the retina from the signals;
means to selectively illuminate the retina through each of the plurality of illumination regions, wherein for some locations on the retina, the pupil regions are illuminated simultaneously and for other locations on the retina, the pupil regions are illuminated sequentially wherein said processor selectively merges portions of the signals associated with the various illumination paths to generate a single composite image with reduced artifacts.

2. A fundus imager as recited in claim 1 , wherein the selective illumination means is a switchable element for selectively blocking one of the illumination regions at a time.

3. A fundus imager as recited in claim 2 , wherein the switchable element is a rotating shutter wheel.

4. A fundus imager as recited in claim 2 , wherein the switchable element is a blade.

5. A fundus imager as recited in claim 2 , wherein the switchable element is an LCD or OLP filter.

6. A fundus imager as recited in claim 1 , wherein light entering the eye is scanned across the retina.

7. A fundus imager as recited in claim 6 , wherein the light entering the eye is scanned using a moving slit in front of the beam of light.

8. A fundus imager as recited in claim 6 , wherein the light entering the eye is scanned using a transverse movement of the beam of light.

9. A fundus imager as recited in claim 6 wherein the fundus imager is descanned.

10. A fundus imager as recited in claim 1 , wherein the selective illumination means is an illumination source with separate selectively operable elements.

11. A fundus imager as recited in claim 1 , wherein the fundus imager is a broad line fundus imager.

12. A method to control the illumination in a fundus imaging system having illumination and detection paths, said method comprising:
separating the illumination and detection paths at a plane conjugate to the pupil of an eye using at least three non-overlapping light transmittable zones, wherein a first zone and a second zone of the three non-overlapping light transmittable zones define illumination regions at the pupil of the eye to transmit light into the eye and a third zone defines a single collection region at the pupil of the eye wherein returning light exiting the eye due to the first and second zones is collected through said single collection region;
for some locations on the retina, sequentially scanning the light through the first zone alone and then through the second zone alone, while collecting light through the third zone to obtain signals corresponding to two different images of the same location on the retina, the first image being associated with the illumination through the first zone and a second image being associated with the illumination through the second zone;
for other locations on the retina, scanning the light through the first and second zones simultaneously while collecting light through the third zone to obtain a third image of a different location of the retina; and
assembling a single composite image of the fundus by selectively merging the signals corresponding to the first, second and third images to reduce artifacts in the single composite image.

13. A method as recited in claim 12 , further comprising illuminating through either the first zone or the second zone, wherein time for collecting the light through the third zone is adjusted based on said illumination.

14. A method of imaging the eye of a subject, comprising:
scanning illuminating light across retinal locations in the eye, the illuminating light passing through a plurality of illumination regions at the pupil wherein for some first locations on the retina, multiple regions at the pupil are simultaneously illuminated and for some second locations on the retina, the individual regions at the pupil are sequentially illuminated;
detecting light returning from the eye through a single collection region at the pupil and generating signals in response thereto for the first and second retinal locations of the eye illuminated by the illumination regions wherein for the second locations on the retina, the signals correspond to multiple images of the same location of the eye, each image associated with a different illumination region; and
combining the signals to generate a single composite image of the eye wherein portions of the signals associated with various illumination regions are selectively merged to reduce artifacts in the image.

15. A method as recited in claim 14 , further comprising compensating for reduced intensity of the signals detected associated with the second locations.

16. A method as recited in claim 14 , where the illuminating light covers a slit shaped area on the retina of the eye.

17. A fundus imager as recited in claim 6 , wherein the light entering the eye is scanned using a scanner.

18. A fundus imager as recited in claim 1 , wherein the pupil regions are illuminated sequentially at central locations of the retina and simultaneously for other locations of the retina.

19. A method as recited in claim 12 , wherein light is scanned sequentially through the first zone and second zone when imaging central locations of the retina, and scanned simultaneously through the first zone and second zone when imaging other locations of the retina.

20. A method as recited in claim 14 , wherein the second locations are at central locations of the retina and the first locations are at other locations of the retina.

Assignees

• Zeiss Carl Meditec Ag

Inventors

• Bublitz Daniel
• Müller Lothar
• Berner Andrea

Classifications

• A61B3/12 Primary

  for looking at the eye fundus, e.g. ophthalmoscopes (A61B3/13 takes precedence) · CPC title

• A61B3/1208 Primary

  Multiple lens hand-held instruments · CPC title

• A61B3/14

  Arrangements specially adapted for eye photography · CPC title

• A61B3/156

  for blocking · CPC title