Co-crystals of tramadol and coxibis
US-10238668-B2 · Mar 26, 2019 · US
Co-crystals of tramadol and coxibs
US10548909B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10548909-B2 |
| Application number | US-201916275437-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 14, 2019 |
| Priority date | Oct 17, 2008 |
| Publication date | Feb 4, 2020 |
| Grant date | Feb 4, 2020 |
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- Title
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- Abstract
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Abstract
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The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of treatment of severe to moderate pain comprising administering to a patient in need thereof an effective amount of a co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2θ] at 14.1, 16.8, 19.0 and 22.7[°], with the 2θ values being obtained using copper radiation (CuKα1 1.54060 Å). 2. The method of treatment of severe to moderate pain of claim 1 , characterized in that the co-crystal shows additional peaks [2θ] at 7.1, 19.9 and 20.5[°]. 3. The method of treatment of severe to moderate pain of claim 2 , characterized in that the co-crystal shows additional peaks [2θ] at 13.6, 13.9, 17.5, 18.0, 19.5, 21.2, 21.3, 21.8, 22.6, 23.6, 24.1, 24.4 and 26.1[°]. 4. A method of treatment of mild pain comprising administering to a patient in need thereof an effective amount of a co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2θ] at 14.1, 16.8, 19.0 and 22.7[°], with the 2θ values being obtained using copper radiation (CuKα1 1.54060 Å). 5. The method of treatment of mild pain of claim 4 , characterized in that the co-crystal shows additional peaks [2θ] at 7.1, 19.9 and 20.5[°]. 6. The method of treatment of mild pain of claim 5 , characterized in that the co-crystal shows additional peaks [2θ] at 13.6, 13.9, 17.5, 18.0, 19.5, 21.2, 21.3, 21.8, 22.6, 23.6, 24.1, 24.4 and 26.1[°].
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
for hyperglycaemia, e.g. antidiabetics · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Centrally acting analgesics, e.g. opioids · CPC title
Drugs for disorders of the nervous system · CPC title
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Frequently asked questions
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- What does patent US10548909B2 cover?
- The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
- Who is the assignee on this patent?
- Esteve Labor Dr, Esteve Pharmaceuticals Sa
- What technology area does this patent fall under?
- Primary CPC classification A61K31/635. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 04 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).