Co-crystals of tramadol and NSAIDs
US-9393220-B2 · Jul 19, 2016 · US
Co-crystals of tramadol and coxibis
US10238668B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10238668-B2 |
| Application number | US-201615207694-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 12, 2016 |
| Priority date | Oct 17, 2008 |
| Publication date | Mar 26, 2019 |
| Grant date | Mar 26, 2019 |
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- Title
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Abstract
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The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
First claim
Opening claim text (preview).
The invention claimed is: 1. A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2θ] at 14.1, 16.8, 19.0 and 22.7[°], with the 2θ values being obtained using copper radiation (CuKα1 1.54060Å). 2. The co-crystal of claim 1 , characterized in that it shows additional peaks at [2θ] 7.1, 19.9 and 20.5[°]. 3. The co-crystal of claim 2 , characterized in that it shows additional peaks [2θ] at 13.6, 13.9, 17.5, 18.0, 19.5, 21.2, 21.3, 21.8, 22.6, 23.6, 24.1, 24.4 and 26.1 [°]. 4. A method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in claim 1 . 5. A method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in claim 2 . 6. A method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in claim 3 .
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
for hyperglycaemia, e.g. antidiabetics · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Centrally acting analgesics, e.g. opioids · CPC title
Drugs for disorders of the nervous system · CPC title
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Frequently asked questions
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- What does patent US10238668B2 cover?
- The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
- Who is the assignee on this patent?
- Esteve Labor Dr
- What technology area does this patent fall under?
- Primary CPC classification C07C217/74. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).