Fully implantable direct myocardium assist device

Patent metadata

Field	Value
Publication number	US-10507271-B2
Application number	US-201715631708-A
Country	US
Kind code	B2
Filing date	Jun 23, 2017
Priority date	Jun 23, 2016
Publication date	Dec 17, 2019
Grant date	Dec 17, 2019

Abstract

The present invention provides an implantable cardiac compression device comprising: an inflatable cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, a channel that connects the inflatable cardiac compression jacket and an expandable fluid reservoir configured to contain a fluid when displaced compresses the inflatable cardiac compression jacket, and a fluid driver operably connected to the inflatable cardiac compression jacket and to the expandable fluid reservoir, wherein the fluid driver is configured to inflate the cardiac compression jacket and to deflate the expandable fluid reservoir during systole of the heart; said driver is further configured to deflate the cardiac compression jacket and to inflate the expandable fluid reservoir during diastole of the heart.

First claim

What is claimed is:

1. An implantable cardiac compression device comprising:
an inflatable cardiac compression device comprising a resilient inner panel in contact with a heart periphery comprising one or more membranes contoured to provide curvatures generally in the shape of the heart to affect the end-diastolic heart volume, an inflatable outer panel comprising a plurality of inflatable membranes positioned completely around the resilient inner panel to inflate to affect the end-systolic heart volume completely around the heart periphery, and a fluid connection in communication with the inflatable outer panel for inflation and deflation;
an expandable fluid reservoir in communication with the fluid connection and is adapted to be positioned adjacent the pericardium and configured to house a fluid when displaced from the inflatable cardiac compression jacket; and
a fluid driver operably connected to the inflatable cardiac compression jacket and to the expandable fluid reservoir, wherein the fluid driver is configured to fill the cardiac compression jacket with the fluid at least partially removed from the expandable fluid reservoir during systolic ejection by the heart and is further configured to fill the expandable fluid reservoir with fluid at least partially removed from the cardiac compression jacket during diastolic filling of the heart.

2. The device of claim 1 , wherein the inflatable membranes are substantially inelastic.

3. The device of claim 1 , wherein a fluid is disposed within the expandable fluid reservoir.

4. The device of claim 1 , wherein the expandable fluid reservoir is adjacent the pericardium.

5. The device of claim 1 , wherein the expandable fluid reservoir is sized to fit between the pericardium and at least one lung to compress the at least one lung when the expandable fluid reservoir expands.

6. The device of claim 1 , wherein the expandable fluid reservoir is sized to fit around at least a portion of the pericardium.

7. The device of claim 1 , wherein the expandable fluid reservoir is configured to expand in the thoracic cavity.

8. The device of claim 1 , wherein the inflatable cardiac compression device comprises between four to twelve at least partially overlapped membranes connected to form a continuous outer edge.

9. The device of claim 1 , wherein the resilient inner panel, the inflatable outer panel, the expandable fluid reservoir or a combination thereof comprise an elastomeric polyurethane, a latex, a polyetherurethane, a polycarbonateurethane, a silicone, a polysiloxaneurethane, a hydrogenated polystyrene-butadiene copolymer, an ethylene-propylene, a dicyclopentadiene terpolymer, hydrogenated poly(styrene-butadiene) copolymer, a poly(tetramethylene-ether glycol) urethanes, a poly(hexamethylenecarbonate-ethylenecarbonate glycol) urethanes or combinations thereof.

10. The device of claim 1 , wherein the cardiac compression jacket, the expandable fluid reservoir or a combination thereof further comprises one or more resilient members comprise individually a metal, an alloy, a memory metal, a composite, a polymer, a plastic, a memory plastic, strands, yarns, strips, or a combination thereof.

11. The device of claim 1 , wherein the cardiac compression jacket further comprises one or more sensors, one or more electrodes to sense electrical activity of the heart to provide pacing stimuli to the heart, one or more electrodes to provide an electrical shock to the heart for defibrillation, one or more electrodes to provide an electrical stimuli to the heart, or a combination thereof in contact with the compression cardiac device.

12. The device of claim 1 , wherein the cardiac compression jacket, the expandable fluid reservoir or both comprise one or more bioactive agents selected from antimicrobials, antibiotics, antimitotics, antiproliferatives, antisecretory agents, non-steroidal anti-inflammatory drugs, immunosuppressive agents, antipolymerases, antiviral agents, antibody targeted therapy agents, prodrugs, free radical scavengers, antioxidants, biologic agents or combinations thereof.

13. The device of claim 1 , wherein the one or more bioactive agents are disposed on a coating.

Assignees

• Texas A & M Univ Sys
• Corinnova Incorporated

Inventors

• Criscione John C
• Leschinsky Boris

Classifications

• A61M1/1037

  Human Necessities · mapped topic

• A61M1/1046

  Human Necessities · mapped topic

• A61M1/107

  Human Necessities · mapped topic

• A61M1/1067

  Human Necessities · mapped topic

• A61M1/122 Primary

  Human Necessities · mapped topic