Inducible tissue constructs and uses thereof
US-2024287463-A1 · Aug 29, 2024 · US
CD34+,CD45−placental stem cell-enriched cell populations
US10494607B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10494607-B2 |
| Application number | US-3017008-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 12, 2008 |
| Priority date | Feb 12, 2007 |
| Publication date | Dec 3, 2019 |
| Grant date | Dec 3, 2019 |
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Abstract
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Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells. Further provided herein is the use of such hepatocytes in the treatment of, and intervention in, for example, trauma, inflammation, and degenerative disorders of the liver. Also provided herein are compositions and methods relating to combinations of nanofibrous scaffolds and adherent placental stem cells and methods of using the same in cartilage repair. Finally, provided herein are compositions and methods relating to nonadherent, CD34+CD45− stem cells from placenta.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of producing an isolated CD34 + , CD45 − hematopoietic placental stem cell population, comprising selecting CD34 + cells from a population of placental cells using antibodies to form a population of CD34 + placental cells, removing from said population of CD34 + placental cells CD45 + cells using antibodies, and combining the resulting cells with a physiologically-acceptable aqueous saline solution, wherein a CD34 + , CD45 − hematopoietic placental stem cell population is produced. 2. The method of claim 1 , wherein said population produces CFU-E or BFU-E when cultured in vitro. 3. The method of claim 1 , wherein at least 50% of cells in said population are CD34 + , CD45 − . 4. The method of claim 1 , wherein at least 70% of cells in said population are CD34 + , CD45 − . 5. The method of claim 1 , wherein at least 90% of cells in said population are CD34 + , CD45 − .
Assignees
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Classifications
Antivirals · CPC title
Drugs for skeletal disorders · CPC title
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title
Polylysine, polyornithine · CPC title
Lipids · CPC title
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- What does patent US10494607B2 cover?
- Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells. Further provided herein is the use of such hepatocytes in the treatment of, and intervention in, for example, trauma, inflammation, and degenerative disorders of the liver. Also provided herein are compositions and methods relating to combinations of nanofibrous scaffolds and adherent placen…
- Who is the assignee on this patent?
- Edinger James W, Hariri Robert J, Wang Jia Lun, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification C12N5/067. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).