Compositions and methods for islet cell transplants
US-2024269194-A1 · Aug 15, 2024 · US
Differentiation of human embryonic stem cells
US9150833B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9150833-B2 |
| Application number | US-97033010-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 16, 2010 |
| Priority date | Dec 23, 2009 |
| Publication date | Oct 6, 2015 |
| Grant date | Oct 6, 2015 |
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Abstract
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The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.
First claim
Opening claim text (preview).
What is claimed is: 1. A method to generate a population of pancreatic endocrine cells that co-express NKX6.1 and insulin, the method comprising the steps of: a) culturing human pluripotent stem cells; b) differentiating the human pluripotent stem cells of step a) into definitive endoderm cells by culturing the human pluripotent stem cells in medium comprising a TGF-β receptor agonist; c) differentiating the definitive endoderm cells of step b) into pancreatic endoderm cells b…
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Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
- C12N5/0676Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9150833B2 cover?
- The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.
- Who is the assignee on this patent?
- Xu Jean, Janssen Biotech Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0676. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).