Method to manufacture microfibers and microcapillaries

Patent metadata

Field	Value
Publication number	US-10450677-B2
Application number	US-201916250963-A
Country	US
Kind code	B2
Filing date	Jan 17, 2019
Priority date	Jan 18, 2018
Publication date	Oct 22, 2019
Grant date	Oct 22, 2019

Abstract

A parylene microcapillary is manufactured by drawing a polyethylene carbonate (PEC) fiber from a 0° C. solution of 12-25% PEC in chloroform to create a PEC fiber that has a constant diameter over several centimeters. Parylene is deposited in a chamber over the PEC fiber, and then the coated PEC fiber is heated above 180° C. This heating melts and decomposes the PEC fiber such that it self-expels from the coating, leaving a microcapillary. The self-expulsion allows for meters-long lengths of microcapillaries. Alternatively, a serpentine fiber channel of PEC is created by deposition, photolithography, and etching within a sandwich of parylene. It is heated above 180° C. to expel the PEC leaving a hollow channel within a mass of parylene. The resulting microcapillaries may have residues of cyclic ethylene carbonate remaining from the decomposed PEC.

First claim

What is claimed is:

1. A method of manufacturing a biocompatible capillary, the method comprising:
dissolving polyethylene carbonate (PEC) in chloroform to create a liquid solution with a mass fraction of 12% to 25% PEC to chloroform;
drawing a PEC fiber by contacting a point with the liquid solution, pulling the point away from the solution, and allowing the chloroform to evaporate to solidify the drawn PEC fiber;
depositing parylene by chemical vapor deposition on the PEC fiber to coat the PEC fiber;
heating the coated PEC fiber to a temperature between 180° C. and a melting point of the parylene, thereby melting the PEC and partially decomposing the PEC into gaseous carbon dioxide, such that the gaseous carbon dioxide pushes the molten PEC out of at least one end of the coated PEC fiber to leave a hollow parylene capillary.

2. The method of claim 1 further comprising:
cooling the solution to 0° C. before the pulling.

3. The method of claim 1 wherein the coated PEC fiber is heated to a temperature between 180° C. and 260° C.

4. The method of claim 1 further comprising:
coiling or serpentining the PEC fiber before placing the PEC fiber in a deposition chamber for the deposition.

5. The method of claim 1 further comprising:
stretching the hollow parylene capillary over a form; and
heating the stretched hollow parylene capillary to a temperature above 200° C. in order to mechanically relax and re-form the hollow parylene capillary.

6. The method of claim 1 wherein the depositing results in a parylene wall thickness between 0.1 μm and 100 μm.

7. The method of claim 1 wherein the parylene is selected from the group consisting of parylene N, parylene C, parylene D, parylene HT, parylene AF-4, and parylene F.

8. The method of claim 1 wherein the pulling of the point is performed at a constant velocity.

9. The method of claim 8 wherein the point is an end of a cylinder.

10. The method of claim 9 wherein the cylinder is a glass tube 762 μm in diameter.

11. The method of claim 8 wherein the constant velocity is between 13 millimeters (mm) per minute to 1100 mm/minute.

12. The method of claim 1 wherein the PEC fiber is drawn to a length greater than 50 millimeters (mm).

13. The method of claim 12 wherein the PEC fiber is drawn to a length greater than 300 mm.

14. A method of manufacturing a biocompatible capillary, the method comprising:
depositing parylene on a substrate;
coating the parylene with polyethylene carbonate (PEC);
etching the PEC to create a coiled or serpentine fiber of PEC on top of parylene;
depositing parylene over the PEC fiber to form a coated PEC fiber;
heating the coated PEC fiber to a temperature between 180° C. and a melting point of the parylene, thereby melting the PEC and partially decomposing the PEC into gaseous carbon dioxide, such that the gaseous carbon dioxide pushes the molten PEC out of at least one end of the coated PEC fiber to leave a hollow parylene capillary;
stretching the hollow parylene capillary over a form; and
heating the stretched hollow parylene capillary to a temperature above 200° C. in order to mechanically relax and re-form the hollow parylene capillary.

15. The method of claim 14 wherein the coated PEC fiber is heated to a temperature between 180° C. and 260° C.

16. The method of claim 14 wherein the etching creates a serpentine fiber of PEC, wherein the hollow parylene capillary has periodic U-shaped sections along its length.

Assignees

• California Inst Of Techn

Inventors

• Chou Tzu-Chieh
• Tai Yu-Chong
• Pi Yudan

Classifications

• B81B1/00

  Devices without movable or flexible elements, e.g. microcapillary devices · CPC title

• D01D5/00

  Formation of filaments, threads, or the like · CPC title

• D01F6/96 Primary

  from other synthetic polymers · CPC title

• D01D10/02

  Heat treatment (heating for finishing D02J13/00) · CPC title

• D01D5/24

  with a hollow structure; Spinnerette packs therefor (D01D5/38 takes precedence; producing tubes of plastic material B29D; addition of agents forming hollow filaments D01F1/08) · CPC title