Adsorption of fluorinated anesthetics within the pores of molecular crystals

Patent metadata

Field	Value
Publication number	US-10449253-B2
Application number	US-201816150787-A
Country	US
Kind code	B2
Filing date	Oct 3, 2018
Priority date	Dec 11, 2014
Publication date	Oct 22, 2019
Grant date	Oct 22, 2019

Abstract

A method of delivering or sequestering anesthetic agents by adsorption of such agents by porous partially fluorinated compounds which display high weight adsorption capacities. Such compounds have a non-covalent organic framework with a central ring, such as hexa, tetra, tri or di substituted benzenes which may be substituted or unsubstituted with alternating electron poor and electron rich groups such as tetra-, tri-, or di-fluorobenzenes, oligocyanobenzenes, oligochlorobenzene, and benzene, pirydone, triazole, pyrazole, pyridine, and substituted benzenes so that the compound forms a porous supramolecular structure; and adsorbs the anesthetic agent within the pores of a the compound.

First claim

What is claimed is:

1. A method of binding an anesthetic gas, said method comprising: contacting the anesthetic gas comprising an anesthetic agent with a non-covalent organic framework, wherein said framework comprises a compound comprising:
a central ring, wherein the central ring is selected from a group comprising:
a 1,2,3,4,5,6-hexasubstituted benzene; a 1,2,4,5-tetrasubstituted benzene; or a 1,4-disubstituted benzene; wherein any of positions 1, 2, 3, 4, 5, and 6 are substituted or are unsubstituted, wherein a substituted group when present is alternatingly selected from:
a first electron poor group comprising: tetra-fluorobenzene, tri-fluorobenzene, di-fluorobenzene, oligocyanobenzenes, and oligochlorobenzene; and
a second electron rich group comprising: benzene, pirydone, triazole, pyrazole, pyridine, and a substituted benzene; wherein the compound forms a porous supramolecular structure; and
adsorbing said anesthetic agent within the pores of said compound.

2. The method of claim 1 , further comprising delivering said anesthetic agent to a patient in need thereof.

3. The method of claim 1 , further comprising sequestering said anesthetic agent from a patient in need thereof.

4. The method of claim 3 , wherein said sequestering occurs post operatively.

5. The method of claim 3 , wherein said sequestering occurs during an operative procedure.

6. The method of claim 3 , wherein said sequestering reduces toxicity.

7. The method of claim 3 wherein said sequestering reduces post-operative stress.

8. The method of claim 1 , wherein said framework has a weight adsorption capacity of about 50% to about 75% for said anesthetic agent.

9. The method of claim 1 , wherein said framework has a weight adsorption capacity of about 60 to about 65% for said anesthetic agent.

10. The method of claim 1 , wherein said anesthetic agents comprise fluorinated anesthetics, non-fluorinated anesthetics or a combination thereof.

11. The method of claim 1 , wherein the anesthetics comprise sevoflurane, enflurane, isoflurane, methoxyflurane, desflurane, halothane, or combinations thereof.

12. The method of claim 1 , wherein said compound comprises pores sizes of about 0.5 to about 2.5 nM.

13. The method of claim 1 , wherein said compound comprises a biosensor.

14. The method of claim 1 , wherein said biosensor is recyclable.

Assignees

• Univ Houston System

Inventors

• Miljanic Ognjen
• Chen Teng-Hao
• Kaveevivitchai Watchareeya

Classifications

• A61K31/08

  acyclic, e.g. paraformaldehyde · CPC title

• A61K31/02

  Halogenated hydrocarbons · CPC title

• A61K47/22 Primary

  Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones · CPC title

• B01D2259/4533

  for medical purposes · CPC title

• B01D2257/2066

  Fluorine · CPC title