Adsorption of fluorinated anesthetics within the pores of molecular crystals

Patent metadata

Field	Value
Publication number	US-10117935-B2
Application number	US-201515534923-A
Country	US
Kind code	B2
Filing date	Dec 10, 2015
Priority date	Dec 11, 2014
Publication date	Nov 6, 2018
Grant date	Nov 6, 2018

Abstract

A method of delivering or sequestering anesthetic agents by adsorption of such agents by porous partially fluorinated compounds which display high weight adsorption capacities.

First claim

What is claimed is:

1. A method of binding an anesthetic agent comprising:
contacting a gas comprising an anesthetic agent with a non-covalent organic framework comprising a compound of:

wherein said compound forms a porous supramolecular structure; and
adsorbing said anesthetic agent within the pores of a compound of Formula 1.

2. The method of claim 1 , further comprising delivering said anesthetic agent to a patient in need thereof.

3. The method of claim 2 , further comprising sequestering said anesthetic agent from a said patient.

4. The method of claim 3 , wherein said sequestering occurs post operatively.

5. The method of claim 3 , wherein said sequestering occurs during an operative procedure.

6. The method of claim 3 , wherein said sequestering reduces toxicity.

7. The method of claim 3 wherein said sequestering reduces post-operative stress.

8. The method of claim 1 , wherein said framework has a weight adsorption capacity of about 50% to about 75% for said anesthetic agent.

9. The method of claim 1 , wherein said framework has a weight adsorption capacity of about 60 to about 65% for said anesthetic agent.

10. The method of claim 5 , wherein said anesthetic agents comprise fluorinated anesthetics, non-fluorinated anesthetics or a combination thereof.

11. The method of claim 1 , wherein the anesthetics comprise sevoflurane, enflurane, isoflurane, methoxyflurane, desflurane, halothane, or combinations thereof.

Assignees

• Univ Houston System

Inventors

• Miljanic Ognjen
• Chen Teng-Hao
• Kaveevivitchai Watchareeya

Classifications

• C07D231/16

  Halogen atoms or nitro radicals · CPC title

• A61K31/08

  acyclic, e.g. paraformaldehyde · CPC title

• B01D2257/2066

  Fluorine · CPC title

• B01D53/02

  by adsorption, e.g. preparative gas chromatography {(solid sorbent compositions B01J20/00, preparation of inorganic compounds or elements C01)} · CPC title

• A61K31/02

  Halogenated hydrocarbons · CPC title