Anti-migration micropatterned stent coating

Patent metadata

Field	Value
Publication number	US-10441406-B2
Application number	US-201313857998-A
Country	US
Kind code	B2
Filing date	Apr 6, 2013
Priority date	Apr 6, 2012
Publication date	Oct 15, 2019
Grant date	Oct 15, 2019

Abstract

An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen and an outer surface; and a polymeric coating adhered to the outer surface of the stent. The polymeric coating includes a base and a plurality of protrusions extending outwardly from the base. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the protrusions apply a force that creates an interlock between the vessel wall and the endoprosthesis.

First claim

The invention claimed is:

1. An endoprosthesis having an expanded state and an unexpanded state, the endoprosthesis comprising:
a stent, wherein the stent has an inner surface defining a lumen, an outer surface, a first end, a second end, and a longitudinal axis extending therebetween, and a thickness defined between the inner surface and the outer surface, wherein the stent has a plurality of openings extending through the thickness;
an adhesive layer disposed on the outer surface of the stent; and
a plurality of spaced apart elongated polymeric strips disposed helically over and adhered to the adhesive layer, each elongated polymeric strip extending at least twice around a circumference of the stent, wherein a portion of the stent is exposed between longitudinally adjacent portions of a single polymeric strip, the plurality of spaced apart polymeric strips comprising a base having an inner surface and an outer surface including a plurality of protrusions extending outwardly from the base, wherein the protrusions are arranged in a micropattern, wherein the base covers the openings of the stent,
wherein each of the plurality of protrusions comprises a micropillar, each micropillar extending between a base portion at the base of the polymeric strip and a top surface at an end of the micropillar opposite the base portion.

2. The endoprosthesis of claim 1 , wherein when the endoprosthesis assumes the expanded state in a lumen defined by a vessel wall, the micropattern of protrusions is adapted to apply a force that creates an interlock between the vessel wall and the endoprosthesis.

3. The endoprosthesis of claim 1 , wherein each of the micropillars includes a columnar portion extending from the base portion toward the top surface, wherein at least a portion of the columnar portion is selected from the group consisting of cylinders, rectangular prisms, and prisms with a polygonal base.

4. The endoprosthesis of claim 3 , wherein the micropillars each have a diameter at the base portion and a height extending between the base portion and the top surface.

5. The endoprosthesis of claim 4 , wherein the diameter is between 1 μm and 100 μm.

6. The endoprosthesis of claim 5 , wherein the diameter is between 14 μm and 18 μm.

7. The endoprosthesis of claim 4 , wherein the height is between 1 μm and 100 μm.

8. The endoprosthesis of claim 7 , wherein the height is between 14 μm and 18 μm.

9. The endoprosthesis of claim 4 , wherein the geometric center of the top surface of the micropillar is separated from the geometric center of the top surface of an adjacent micropillar by a distance greater than the diameter of the micropillar.

10. The endoprosthesis of claim 1 , wherein each protrusion of the micropattern has a height between the base portion and the top surface, and a diameter at the base portion, wherein the height is between 1 μm and 100 μm, wherein the diameter is between 1 μm and 100 μm, and wherein a ratio between height and the diameter is between 1 and 1.3.

11. The endoprosthesis of claim 1 , wherein the polymeric member is made from a polymeric material selected from the group consisting of hydrogels and silicones.

12. The endoprosthesis of claim 1 , wherein the protrusions of the micropattern are hollow.

13. The endoprosthesis of claim 1 , wherein the micropattern includes protrusions of a first configuration and protrusions of at least a second configuration.

14. The endoprosthesis of claim 1 , wherein first and second opposing walls of the micropillar extend between the base portion and the top surface at first and second angles, respectively, wherein the first and second angles are different from each other, and a geometric center of the base portion is offset laterally from a geometric center of the top surface.

15. The endoprosthesis of claim 1 , wherein the micropillars have an outer surface, wherein at least some of the micropillars have recesses in their outer surface, the recesses distributed over substantially the entire outer surface.

16. An endoprosthesis having an expanded state and an unexpanded state, the endoprosthesis comprising:
a stent, wherein the stent has an inner surface defining a lumen, an outer surface, a first end, a second end, and a thickness defined between the inner surface and the outer surface, wherein the stent has a plurality of openings extending through the thickness; and
a polymeric member adhered to the outer surface of the stent, the polymeric member comprising a base having an inner surface adhered to the stent and an outer surface including a plurality of elongate protrusions extending outwardly from the base, wherein the plurality of elongate protrusions are arranged in one or more different micropatterns, wherein each of the plurality of elongate protrusions extends from the base to a concave top surface.

17. The endoprosthesis of claim 16 , wherein each elongate protrusion of the plurality of elongate protrusions has a height and a diameter at a base of the protrusion, wherein height is between 1 μm and 100 μm, wherein the diameter is between 1 μm and 100 μm, and wherein a ratio between the height and the diameter is between 1 and 1.3.

18. The endoprosthesis of claim 17 , wherein a geometric center of each elongate protrusion of the plurality of elongate protrusions is spaced apart from a geometric center of adjacent elongate protrusions by a spacing between elongate protrusions, wherein a ratio of the spacing to the diameter is between 2.1 and 2.4.

19. An endoprosthesis having an expanded state and an unexpanded state, the endoprosthesis comprising:
a stent, wherein the stent has an inner surface defining a lumen, an outer surface, a first end, a second end, and a longitudinal axis extending therebetween, and a thickness defined between the inner surface and the outer surface, wherein the stent has a plurality of openings extending through the thickness; and
a plurality of spaced apart elongated polymeric strips adhered to the stent with an adhesive layer, each of the plurality of elongated spaced apart polymeric strips extending helically around a circumference of the stent at least twice, each strip comprising a base having an inner surface facing the stent and an outer surface including a plurality of protrusions extending outwardly from the base, wherein the plurality of protrusions are arranged in one or more different micropatterns, wherein each of the plurality of protrusions extends between a base portion at the base of the polymeric strip and a top surface at an end of the protrusion opposite the base portion, wherein the top surface of each protrusion is concave, wherein the outer surface of the stent is exposed between longitudinally adjacent portions of a single polymeric strip and between the plurality of spaced apart polymeric strips.

20. The endoprosthesis of claim 19 , wherein for at least some of the plurality of protrusions, first and second opposing walls of each protrusion extend between the base and a top surface of the protrusion at first and second angles, respectively, wherein the first and second angles are different from each other.

21. The endoprosthesis of claim 19 , wherein a geometric center at the base of at least some of the plurality of protrusions is offset laterally from a geometric center of a top surface of the protrusion.

Assignees

• Boston Scient Scimed Inc

Inventors

• Firstenberg Laura Elizabeth
• Mcleod Claire M
• Taylor Shannon
• Lai Andrea
• Lam Sandra

Classifications

• A61F2250/0026

  differing in surface structures · CPC title

• A61F2/0077

  Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence) · CPC title

• A61F2002/044

  Oesophagi or esophagi or gullets · CPC title

• A61F2250/0039

  differing in diameter · CPC title

• A61F2230/0078

  hyperboloidal · CPC title