Menthol-derivative compounds and use thereof as oral and systemic active agents

Patent metadata

Field	Value
Publication number	US-10426752-B2
Application number	US-200913258142-A
Country	US
Kind code	B2
Filing date	Apr 1, 2009
Priority date	Apr 1, 2009
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.

First claim

What is claimed:

1. A method for providing one or more oral care beneficial effects, selected from anti-inflammation and anti-bone loss effects, to a subject in need thereof, comprising administering to the oral cavity of the subject an amount from 0.05 wt. % to 5 wt. % of at least one menthol-derivative compound conforming to Formula 1 to a subject:

wherein
X is an oxygen atom or an NH radical; and
R is an unsubstituted or substituted aryl radical, and

in combination with a water-swellable synthetic, anionic, linear copolymeric polycarboxylate.

2. The method of claim 1 , wherein X is an NH radical.

3. The method of claim 2 , wherein R is a substituted aryl radical.

4. The method of claim 3 , wherein R is:

and wherein Y is a hydroxyl or cyano radical.

5. The method of claim 4 , wherein the compound is:

6. The method of claim 1 , wherein X is an oxygen atom.

7. The method of claim 6 , wherein R is at least one member chosen from:

8. The method of claim 1 , wherein the benefit is biofilm anti-attachment.

Assignees

• Trivedi Harsh M
• Xu Tao
• Miksa Davide
• Worrell Cortney
• Macias Chanda
• Yang Ying
• Hu Yanan
• Colgate Palmolive Co

Inventors

• Trivedi Harsh M
• Xu Tao
• Miksa Davide
• Worrell Cortney
• Macias Chanda
• Yang Ying
• Hu Yanan

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P39/06

  Free radical scavengers or antioxidants · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title