Oral care compositions and methods

Patent metadata

Field	Value
Publication number	US-9320696-B2
Application number	US-201414505496-A
Country	US
Kind code	B2
Filing date	Oct 2, 2014
Priority date	Dec 21, 2009
Publication date	Apr 26, 2016
Grant date	Apr 26, 2016

Abstract

Described herein are compositions comprising a MMP-13 inhibitor, and methods of using the same.

First claim

What is claimed is:

1. A composition comprising a therapeutically effective amount of a MMP-13 inhibitor, and an orally acceptable carrier, wherein the MMP-13 inhibitor is 4-acetamidophenyl 2-isopropyl-5-methylcyclohexyl carbonate.

2. The composition of claim 1 , wherein the composition further comprises an MMP-13 inhibitor selected from the group consisting of cranberry extract non-dialyzable material, acetyl keto β-boswellic acid, resveratrol, and 2-isopropyl-5-methylcyclohexyl 2-hydroxyphenylcarbamate, and combinations thereof.

3. The composition of claim 2 , wherein the MMP-13 inhibitor comprises cranberry extract non-dialyzable material.

4. The composition of claim 2 , wherein the MMP-13 inhibitor comprises acetyl keto β-boswellic acid.

5. The composition of claim 2 , wherein the MMP-13 inhibitor comprises resveratrol.

6. The composition of claim 2 , wherein the MMP-13 inhibitor comprises 2-isopropyl-5-methylcyclohex 2-hydroxyphenylcarbamate.

7. The composition of claim 1 , wherein the composition is a dentifrice.

8. The composition of claim 7 , wherein the dentifrice is selected from the group consisting of: toothpaste; deep striped toothpaste; surface striped toothpaste; multi-layered toothpaste; a gel surrounding toothpaste; powder; beads; mouthwash; mouth rinses; lozenge; dental gel; a periodontal gel; a liquid suitable for painting a dental surface; a chewing gum; a dissolvable, partially dissolvable or non-dissolvable film or strip; a wafer; a wipe or towelette; an implant; a foam; a troche; a dental floss, liquid formulated for oral application in a small portable bottle; liquid formulated for oral application in a small portable drop-generating bottle; a soft pliable tablet; or a combination of two or more thereof.

Assignees

• Colgate Palmolive Co

Inventors

• Wang Wei
• Barnes Virginia
• Trivedi Harsh M
• Xu Tao

Classifications

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61P19/08

  for bone diseases, e.g. rachitism, Paget's disease · CPC title

• A61K31/27

  of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine · CPC title

• A61K31/19 Primary

  Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) · CPC title

• A61K31/265

  of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid · CPC title