Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle

Patent metadata

Field	Value
Publication number	US-10426745-B2
Application number	US-201615555794-A
Country	US
Kind code	B2
Filing date	Mar 4, 2016
Priority date	Mar 6, 2015
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

Provided herein are polymers comprising Metformin residues (“PolyMet”) as useful therapeutic agents, delivery vehicles and transfection agents for nucleotides. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering PolyMet as a therapeutic agent to combat the disease or condition. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering a therapeutic agent in a delivery vehicle that comprises PolyMet. Further provided herein are methods for making PolyMet.

First claim

That which is claimed:

1. A nanoparticle comprising:
i. a lipid outer membrane; and
ii. a polymer encapsulated by the lipid outer membrane, said polymer having the following chemical formula I

wherein, p is 1 or 2, n is an integer from two (2) to 10,000;
and
wherein, X is hydrogen or a residue of Metformin having the formula:

wherein at least 5% of X in the polymer is a residue of Metformin.

2. The nanoparticle of claim 1 further comprising a cargo complexed with
the polymer, wherein the cargo is a therapeutic agent.

3. A method of delaying, inhibiting, decreasing, slowing or ameliorating type 2 diabetes or cancer by administering the nanoparticle of claim 1 to a subject.

Assignees

• Univ North Carolina Chapel Hill

Inventors

• Huang Leaf
• Zhao Yi
• Guo Shutao
• Shi Kai

Classifications

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61K47/59

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes · CPC title

• A61K48/00

  Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy · CPC title

• C12N15/88

  using microencapsulation, e.g. using {amphiphile} liposome vesicle · CPC title