Film compositions for oral use

Patent metadata

Field	Value
Publication number	US-10426720-B2
Application number	US-201315107590-A
Country	US
Kind code	B2
Filing date	Dec 23, 2013
Priority date	Dec 23, 2013
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

Described herein are oral compositions comprising a film, wherein the film comprises a dye entrapped in a silica sol-gel.

First claim

The invention claimed is:

1. An oral care composition comprising:
(i) flakes of a water dissolvable or soluble film comprising:
(a) about 15 to about 40% by weight of a water soluble cellulose polymer in the form of a polymer matrix, wherein the cellulose polymer is hydroxypropylmethyl cellulose; and
(b) a dye which is entrapped in a silica sol-gel, wherein the silica sol-gel is entrained in the polymer matrix, and
(c) betaine; and

(ii) an orally acceptable carrier vehicle,
wherein the film flakes are single-layer film flakes and are pliable;
wherein the hydroxypropylmethyl cellulose is a blend of a first hydroxypropylmethyl cellulose having a viscostity ranging from 4 to 6 mPas, and a second hydroxypropylmethyl cellulose having a viscosity ranging from 40 cps to 60 mPas; and
wherein the first and second hydroxylpropylmethyl cellulose are present in a weight ratio of about 1:1.

2. The composition of claim 1 , wherein the cellulose polymer further comprises one or more of hydroxyethylpropyl cellulose, hydroxybutyl methyl cellulose, carboxymethyl cellulose and mixtures thereof.

3. The composition according to claim 1 , wherein the film further comprises a plasticizer selected from sorbitol, propylene glycol, glycerol, and polyethylene glycol.

4. The composition according to claim 1 , wherein the film is dissolved after a period of greater than 30 seconds and less than 180 seconds of brushing, scrubbing or agitation in the presence of water.

5. The composition according to claim 1 wherein the average thickness of the film is 1.5-3 mil.

6. The composition according to claim 1 wherein the dye is FD&C Blue#1.

7. The composition according to claim 1 , comprising, by dry weight of the film, 10-30% propylene glycol; 1-5% betaine; and 15-30% dye entrapped silica sol-gel.

8. The composition according to claim 1 which is stable upon storage at about room temperature for 1 month, 2 months, 3 months, 6 months, 1 year or 2 years.

9. The composition according to claim 1 , which is a clear gel toothpaste; wherein the dye is released from said film after brushing for a period of 30 to 120 seconds.

10. A method of cleaning the teeth comprising brushing the teeth with a composition according to claim 1 , wherein brushing is continued until the film releases all of the dye; thereby providing a color signal to the user of adequate brushing.

11. The composition according to claim 1 , wherein the composition does not contain polysorbate 80.

12. The compositition according to claim 1 , wherein the film flakes have a particle size of about 10 to about 100 mesh.

13. The compositition according to claim 1 , wherein the film flakes have a particle size of about 20 to about 60 mesh.

14. The compositition according to claim 1 , wherein the film flakes have a particle size of about 30 to about 50 mesh.

15. An oral care composition comprising:
(i) flakes of a water dissolvable or soluble film comprising:
(a) a polymer matrix comprising a water soluble cellulose polymer that is present in an amount ranging from about 15 wt. % to about 40 wt. % based on the total weight of the oral care composition, the cellulose polymer comprising a blend of:
a first hydroxypropylmethyl cellulose having a viscostity ranging from 4 to 6 mPas, and
a second hydroxypropylmethyl cellulose having a viscosity ranging from 40 cps to 60 mPas; and

(b) a dye which is entrapped in a silica sol-gel, wherein the silica sol-gel is entrained in the polymer matrix, wherein the dye-entrapped silica sol-gel is present in an amount ranging from about 15 wt. % to about 30 wt. % based on the total weight of the oral care composition and the dye is FD&C Blue#1; and
(c) betaine present in an amount ranging from about 1 wt. % to about 5 wt. % based on the total weight of the oral care composition; and

(ii) an orally acceptable carrier vehicle,

wherein the film flakes have a particle size of about 30 to about 50 mesh;
wherein the first hydroxypropylmethyl celluose and the second hydroxypropylmethyl cellulose are present in a weight ratio of about 1:1.

Assignees

• Colgate Palmolive Co

Inventors

• Szewczyk Gregory
• Dogu Nihal
• Jogun Suzanne

Classifications

• A61K9/006

  Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays · CPC title

• A61K2800/262

  Transparent; Translucent · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K2800/52

  Stabilizers · CPC title

• A61K8/44

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title