Linear inspection system
US-2015377796-A1 · Dec 31, 2015 · US
Composition and method for monitoring lipid
US10401295B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10401295-B2 |
| Application number | US-201515313580-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 28, 2015 |
| Priority date | May 28, 2014 |
| Publication date | Sep 3, 2019 |
| Grant date | Sep 3, 2019 |
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Abstract
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A method of detecting a condition in a subject comprises the steps of contacting cells of the subject with single-walled carbon nanotubes (SWCNTs), monitoring photoluminescence emitted by SWCNTs internalized into the cells and generating an SWCNT emission profile, comparing the SWCNT emission profile to a control emission profile for the SWCNTs to produce a result, and determining a likelihood of having the condition in the subject based on the result from the comparing step. Also disclosed is a method for screening agents capable of changing endocytic environment using SWCNTs.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of detecting elevated lysosomal lipid content in in vitro HeLa cells using single-walled carbon nanotubes (SWCNTs), comprising: contacting the HeLa cells in vitro with SWCNTs, wherein said contacting provides SWCNTs internalized into said cells; monitoring photoluminescence emitted by SWCNTs internalized into said cells and generating an SWCNT emission profile; wherein elevated lysosomal lipid content is detected upon a blue-shift in the SWCNT emission profile from a control emission profile; and wherein the SWCNTs are purified (8,6) SWCNTs encapsulated with ss(GT) 6 oligonucleotides.
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Classifications
Measuring fluorescence of biological material, e.g. DNA, RNA, cells (G01N21/6428 takes precedence) · CPC title
Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title
Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title
- G01N21/6489Primary
Photoluminescence of semiconductors · CPC title
for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title
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Frequently asked questions
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- What does patent US10401295B2 cover?
- A method of detecting a condition in a subject comprises the steps of contacting cells of the subject with single-walled carbon nanotubes (SWCNTs), monitoring photoluminescence emitted by SWCNTs internalized into the cells and generating an SWCNT emission profile, comparing the SWCNT emission profile to a control emission profile for the SWCNTs to produce a result, and determining a likelihood …
- Who is the assignee on this patent?
- Memorial Sloan Kettering Cancer Center
- What technology area does this patent fall under?
- Primary CPC classification G01N21/6489. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Sep 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).