Tocopherol and tocopheryl quinone derivatives as correctors of lysosomal storage disorders

Patent metadata

Field	Value
Publication number	US-10370348-B2
Application number	US-201715608753-A
Country	US
Kind code	B2
Filing date	May 30, 2017
Priority date	Nov 16, 2012
Publication date	Aug 6, 2019
Grant date	Aug 6, 2019

Abstract

The subject invention relates to improved tocopheryl quinine derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorder, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.

First claim

What is claimed is:

1. A tocopheryl quinone derivative of formula (I):

wherein
R 1 , R 2 , and R 3 independently are hydrogen, halogen, alkyl, or fluoroalkyl;
R a and R b independently are hydrogen or absent in each repeat;
X is halogen; and
the dotted line bonds indicate single or double bonds.

Assignees

• Us Health

Inventors

• Marugan Juan Jose
• Zheng Wei
• Xiao Jingbo
• Mckew John

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A61K31/355

  Tocopherols, e.g. vitamin E · CPC title

• A61K31/122

  having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin · CPC title