Scaffolds comprising nanoelectronic components for cells, tissues, and other applications

Patent metadata

Field	Value
Publication number	US-10369255-B2
Application number	US-201615216068-A
Country	US
Kind code	B2
Filing date	Jul 21, 2016
Priority date	Sep 7, 2012
Publication date	Aug 6, 2019
Grant date	Aug 6, 2019

Abstract

The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.

First claim

What is claimed is:

1. An article, comprising:
a structure comprising a biocompatible polymer and having an open porosity of at least about 50%, the structure further comprising an electrical circuit at least partially defined by one or more metal leads having a maximum cross-sectional dimension of less than about 5 micrometers, wherein the electrical circuit is in electrical communication with a computer.

2. The article of claim 1 , wherein the structure comprises polymeric fibers.

3. The article of claim 1 , wherein the structure comprises one or more polymeric constructs.

4. The article of claim 3 , wherein the polymeric constructs have a largest cross-sectional dimension of less than about 5 micrometers.

5. The article of claim 1 , wherein the structure comprises a biodegradable polymer.

6. The article of claim 1 , wherein the structure comprises an extracellular matrix protein.

7. The article of claim 1 , wherein the structure has an areal mass density of less than about 60 micrograms/cm 2 .

8. The article of claim 1 , wherein the structure has an average pore size of at least about 100 micrometers.

9. The article of claim 1 , wherein electrical circuit comprises a field effect transistor.

10. The article of claim 1 , wherein the electrical circuit comprises one or more nanoscale wires.

11. The article of claim 10 , wherein the electrical circuit comprises one or more semiconductor nanoscale wires.

12. The article of claim 10 , wherein at least one of the nanoscale wires is responsive to an electrical property external to the nanoscale wire.

13. The article of claim 10 , wherein the structure has a density of nanoscale wires of at least about 30 nanoscale wires/mm 3 .

14. The article of claim 10 , wherein at least about 50% of the nanoscale wires within the structure are individually electronically addressable, such that voltage or current may be applied to a nanoscale wire without simultaneously applying the voltage or the current to another nanoscale wire.

15. The article of claim 10 , wherein at least 50% of the nanoscale wires within the structure form portions of one or more electrical circuits extending externally of the structure.

16. The article of claim 1 , wherein the structure comprises a photoresist.

17. The article of claim 1 , wherein the electrical circuit is in electrical communication with a transmitter.

18. The article of claim 1 , wherein the article further comprises cells on the structure.

19. The article of claim 1 , wherein the article further comprises an in vitro biological tissue containing the structure.

20. An article, comprising:
a structure comprising a biocompatible polymer and having an open porosity of at least about 50%, the structure further comprising an electrical circuit at least partially defined by one or more metal leads having a maximum cross-sectional dimension of less than about 5 micrometers, wherein the electrical circuit is in electrical communication with a transmitter.

21. The article of claim 20 , wherein the structure comprises polymeric fibers.

22. The article of claim 20 , wherein the structure comprises a biodegradable polymer.

23. The article of claim 20 , wherein the structure comprises an extracellular matrix protein.

24. The article of claim 20 , wherein electrical circuit comprises a field effect transistor.

25. The article of claim 20 , wherein the electrical circuit comprises one or more nanoscale wires.

26. The article of claim 25 , wherein the electrical circuit comprises one or more semiconductor nanoscale wires.

27. The article of claim 25 , wherein at least about 50% of the nanoscale wires within the structure are individually electronically addressable, such that voltage or current may be applied to a nanoscale wire without simultaneously applying the voltage or the current to another nanoscale wire.

28. The article of claim 20 , wherein the structure comprises a photoresist.

29. The article of claim 20 , wherein the article further comprises cells on the structure.

30. The article of claim 20 , wherein the article further comprises an in vitro biological tissue containing the structure.

Assignees

• Harvard College
• Massachusetts Inst Technology
• Childrens Medical Center

Inventors

• Lieber Charles M
• Liu Jia
• Tian Bozhi
• Dvir Tal
• Langer Robert S
• Kohane Daniel S

Classifications

• A61L27/56 Primary

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L27/025

  Other specific inorganic materials not covered by A61L27/04 - A61L27/12 · CPC title

• A61L27/38

  containing added animal cells (organs or tissue containing native cells A61L27/36) · CPC title

• A61L27/507

  for artificial blood vessels (apparatus for applying cells on a blood vessel prosthesis A61F2/062) · CPC title