Synchronization of ion generation with cycling of a discontinuous atmospheric interface

Patent metadata

Field	Value
Publication number	US-10361073-B2
Application number	US-201615355501-A
Country	US
Kind code	B2
Filing date	Nov 18, 2016
Priority date	Jan 20, 2011
Publication date	Jul 23, 2019
Grant date	Jul 23, 2019

Abstract

The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

First claim

What is claimed is:

1. An online reaction monitoring system, the system comprising:
a reaction vessel comprising an outlet port;
a channel that extends from within the outlet port;
an electrode operably associated with a distal end of the channel, wherein the electrode is external to the channel and does not physically contact the channel or a liquid or vapor within the channel; and
a mass spectrometer.

2. The system according to claim 1 , wherein the electrode is positioned to inductively interact with a distal end of the channel.

3. The system according to claim 1 , wherein the reaction vessel comprises one or more inlet ports.

4. The system according to claim 3 , wherein the system further comprises a gas source operably coupled to the reaction vessel through one of the one or more inlet ports.

5. The system according to claim 1 , wherein the channel extends into the reaction vessel.

6. The system according to claim 1 , wherein the channel comprises one or more splitters.

7. The system according to claim 6 , wherein a first splitter withdraws a portion of a liquid from the channel.

8. The system according to claim 7 , wherein a second splitter is coupled to a nebulizing gas source in order to introduce a nebulizing gas into the channel.

9. The system according to claim 1 , further comprising a heating element operably associated with the reaction vessel.

10. The system according to claim 1 , wherein the mass spectrometer is a miniature mass spectrometer.

11. An online reaction monitoring system, the system comprising:
a reaction vessel comprising an outlet port;
a channel that extends from within the outlet port;
an electrode positioned to inductively interact with a distal end of the channel, wherein the electrode is external to the channel and does not physically contact the channel or a liquid or vapor within the channel and the electrode produces a pulsed current; and
a mass spectrometer.

12. The system according to claim 11 , wherein the pulsed current is a pulsed DC current.

13. The system according to claim 11 , wherein the reaction vessel comprises one or more inlet ports.

14. The system according to claim 13 , wherein the system further comprises a gas source operably coupled to the reaction vessel through one of the one or more inlet ports.

15. The system according to claim 11 , wherein the channel extends into the reaction vessel.

16. The system according to claim 11 , wherein the channel comprises one or more splitters.

17. The system according to claim 16 , wherein a first splitter withdraws a portion of a liquid from the channel.

18. The system according to claim 17 , wherein a second splitter is coupled to a nebulizing gas source in order to introduce a nebulizing gas into the channel.

19. The system according to claim 11 , further comprising a heating element operably associated with the reaction vessel.

20. The system according to claim 11 , wherein the mass spectrometer is a miniature mass spectrometer.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Duncan Jason
• Huang Guangming
• Li Guangtao
• Yan Xin
• Sokol Ewa
• Li Xin

Classifications

• H01J49/0445

  with means for introducing as a spray, a jet or an aerosol (electrospray ion sources H01J49/165) · CPC title

• H01J49/045 Primary

  with means for using a nebulising gas, i.e. pneumatically assisted · CPC title

• G01N27/62 Primary

  by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode · CPC title

• Y10T436/24

  Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry · CPC title

• H01J49/0018

  Microminiaturised spectrometers, e.g. chip-integrated devices, Micro-Electro-Mechanical Systems [MEMS] · CPC title