US10350310B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10350310-B2 |
| Application number | US-201816101544-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 13, 2018 |
| Priority date | Jan 28, 2010 |
| Publication date | Jul 16, 2019 |
| Grant date | Jul 16, 2019 |
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The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
Opening claim text (preview).
The invention claimed is: 1. A solid cyclodextrin-bonded indocyanine of formula (16): wherein: at least a portion of a naphthyl group of the indocyanine is included in a cavity of the cyclodextrin; and the indocyanine has a counter anion. 2. A composition, comprising the solid cyclodextrin-bonded indocyanine of claim 1 . 3. The solid cyclodextrin-bonded indocyanine of claim 1 , wherein the counter anion is a chloride anion. 4. A composition, comprising the solid cyclodextrin-bonded indocyanine of claim 3 . 5. A solid cyclodextrin-bonded indocyanine of formula (20): wherein: at least a portion of a naphthyl group of the indocyanine is included in a cavity of the cyclodextrin; and the indocyanine has a counter anion. 6. A composition, comprising the solid cyclodextrin-bonded indocyanine of claim 5 . 7. The solid cyclodextrin-bonded indocyanine of claim 5 , wherein the counter anion is a chloride anion. 8. A composition, comprising the solid cyclodextrin-bonded indocyanine of claim 7 .
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