Degradable implantable medical devices

Patent metadata

Field	Value
Publication number	US-10350093-B2
Application number	US-201514998288-A
Country	US
Kind code	B2
Filing date	Dec 23, 2015
Priority date	Apr 5, 2005
Publication date	Jul 16, 2019
Grant date	Jul 16, 2019

Abstract

Devices and methods are provided for an implantable medical device which is degradable over a clinically relevant period of time. The medical devices may have the form of implants, graft implants, vascular implants, non vascular implants, wound closure implants, sutures, drug delivery implants, biologic delivery implants, urinary tract implants, inter-uterine implants, organ implants, bone implants including bone plates, bone screws, dental implants, spinal disks, or the like. In preferred embodiments, the implantable medical device comprises an implantable luminal prosthesis, such as vascular and non-vascular stents and stents grafts.

First claim

What is claimed is:

1. A degradable, implantable stent comprising:
a tubular body comprising a corrodible metal or metal alloy including at least one corrosion enhancing element within the corrodible metal or metal alloy and at least one corrosion resisting element; and
a passivation layer or a coating incorporated in or covering at least a portion of the body;
wherein one metal in the corrodible metal alloy comprises at least 90% of the metal alloy; and
wherein said stent degrades in about one month to about five years in a physiological environment.

2. A stent of claim 1 , wherein the metal alloy is selected from the group consisting of bismuth, cobalt, copper, indium, iridium, iron, magnesium, molybdenum, nickel, niobium, silver, tin, tungsten, zinc, zirconium and combinations thereof.

3. A stent of claim 1 wherein the metal comprises bismuth, carbon, chromium, cobalt, copper, indium, iridium, iron, magnesium, molybdenum, nickel, niobium, silicon, silver, tin, titanium, tungsten, vanadium, zinc, zirconium, or a combination thereof.

4. A stent of claim 1 , wherein the corrosion enhancing agent is selected from the group consisting of calcium, carbon, copper, iron, magnesium, sulfide, silicon, silicates, sulfur, and combinations thereof.

5. A stent of claim 1 , wherein the corrosion resisting element comprises chromium, nickel or molybdenum.

6. A stent of claim 1 , wherein the at least one corrosion enhancing element is greater than approximately 0.01% of the corrodible metal or metal alloy composition by weight.

7. A stent of claim 1 , wherein the at least one corrosion resisting element is less than approximately 15% of the corrodible metal or metal alloy composition by weight.

8. A stent as in claim 1 , wherein the coating covers at least a portion of the tubular body and the coating comprises a degradable polymer.

9. A stent as in claim 8 , wherein the degradable polymer is selected from the group consisting of poly(lactic acids), poly(D-lactic acid), poly(L-lactic acid), poly(DL-lactic acid), copolymers of poly(lactic acids), poly lactates, poly(glycolic acid), poly glycolates, poly dioxanone, poly(ethyl glutamate), poly(hydroxybutyrate), polyhydroxyvalerate, poly (ε-caprolactone), polyanhydride, poly(ortho esters); poly(ether esters), poly (iminocarbonates), poly alkylene carbonates, polyethylene carbonate, poly trimethylene carbonate, starch based polymers, polyester amides, polyester amines, polycyanoacrylates, polyphosphazenes, poly ethylene glycols, poly ethylene oxide, N-vinyl-2-pyrrolidone, aliphatic polyesters, copolymers of poly(D-lactic acid) and poly(ε-caprolactone), copolymers of poly(L-lactic acid) and poly(ε-caprolactone), and copolymers of poly(DL-lactic acid) and poly(ε-caprolactone).

10. A stent as in claim 1 , further comprising at least one therapeutic agent.

11. A stent as in claim 10 , wherein at least one of the therapeutic agents is selected from the group consisting of immunomodulators, anti-cancer agents, anti-proliferative agents, anti-inflammatory agents, antithrombotic agents, antiplatelet agents, antifungal agents, antidiabetic agents, antihyperlipidimia agents, antiangiogenic agents, angiogenic agents, antihypertensive agents, contraceptive agents, anti depressant agents, anti seizure agents, pain control agents, anti-addictive agents, healing promoting drugs, fertility agents, metabolism control agents, and combinations thereof.

12. A stent as in claim 10 , wherein at least one of the therapeutic agents is selected from the group consisting of acivicin, aclarubicin, acodazole, acronycine, adozelesin, alanosine, aldesleukin, allopurinol sodium, altretamine, aminoglutethimide, amonafide, ampligen, amusacrine, androgens, anguidine, aphidicolin glycinate, asaley, asparaginase, 5-azacitidine, azathioprine, Bacillus calmette-guerin (BCG), Baker's Antifol (soluble), beta-2′-deoxythioguanosine, bisantrene HCl, bleomycin sulfate, busulfan, buthionine sulfoximine, BWA 773U82 (Crisnatol mesylate), BW 502U83.HCl (arylmethylaminopropanediols), ceracemide, carbetimer, carboplatin, carmustine, chlorambucil, chloroquinoxaline-sulfonamide, chlorozotocin, chromomycin A3 (Toyomycin), cisplatin, cladribine, corticosteroids, Corynebacterium parvum , CPT-11 (Camptothecin-11/Irinotecan), crisnatol, cyclocytidine, cyclophosphamide, cytarabine, cytembena, dabis maleate, dacarbazine, dactinomycin, daunorubicin HCl, deazauridine, dexrazoxane, dianhydrogalactitol, diaziquone, dibromodulcitol, didemnin B, diethyldithiocarbamate, diglycoaldehyde, dihydro-5-azacytidine, doxorubicin, echinomycin, edatrexate, edelfosine, eflomithine, buffered intrathecal electrolyte/dextrose injection, elsamitrucin, epirubicin, esorubicin, estramustine phosphate, estrogens, etanidazole, ethiofos, etoposide, fadrazole, fazarabine, fenretinide, filgrastim, finasteride, flavone acetic acid, floxuridine, fludarabine phosphate, 5-fluorouracil, 20% intravascular perflurochemical emulsion, flutamide, gallium nitrate, gemcitabine, goserelin acetate, hepsulfam, hexamethylene bisacetamide, homoharringtonine, hydrazine sulfate, 4-hydroxyandrostenedione, hydroxyurea, idarubicin HCl, ifosfamide, interferon alfa, interferon beta, interferon gamma, interleukin-1 alpha and beta, interleukin-3, interleukin-4, interleukin-6,4-ipomeanol, iproplatin, isotretinoin, leucovorin calcium, leuprolide acetate, levamisole, liposomal daunorubicin, liposome encapsulated doxorubicin, lomustine, lonidamine, maytansine, mechlorethamine hydrochloride, melphalan, menogaril, merbarone, 6-mercaptopurine, mesna, methanol extraction residue of Bacillus calmette-guerin, methotrexate, N-methylformamide, mifepristone, mitoguazone, mitomycin-C, mitotane, mitoxantrone hydrochloride, monocyte/macrophage colony-stimulating factor, nabilone, nafoxidine, neocarzinostatin, octreotide acetate, ormaplatin, oxaliplatin, PALA (N-(phosphonacetyl)-L-aspartic acid), pentostatin, piperazinedione, pipobroman, pirarubicin, piritrexim, piroxantrone hydrochloride, granulocyte macrophage colony stimulating factor/interleukin-3 fusion protein (PIXY-321), plicamycin, porfimer sodium, prednimustine, procarbazine, progestins, pyrazofurin, razoxane, sargramostim, semustine, spirogermanium, spiromustine, streptonigrin, streptozocin, sulofenur, suramin sodium, tamoxifen, taxotere, tegafur, teniposide, terephthalamidine, teroxirone, thioguanine, thiotepa, thymidine, tiazofurin, topotecan, toremifene, tretinoin, trifluoperazine hydrochloride, trifluridine, trimetrexate, tumor necrosis factor, uracil mustard, vinblastine sulfate, vincristine sulfate, vindesine, vinorelbine, vinzolidine, Yoshi 864 (1-propanol-3,3′-iminodi-dimethanesulfonate [ester], hydrochloride), zorubicin, epothilone D, epothilone C, paclitaxel, docetaxel, ABJ879 (20-desmethyl-20-methylsulfanyl epothilone B), patupilone, MN-029 (Denibulin), BMS247550 (Ixabepilon), ecteinascidins, tetrahydroisoquinoline alkaloid, sirolimus, actinomycin, methotrexate, antiopeptin, vincristine, mitomycin, 2-chlorodeoxyadenosine, caspofungin, farnesylated dibenzodiazepinone, ECO-4601 (Dibenzodiazepoine), fluconazole, follistatin, leptin, midkine, angiogenin, angiopoietin-1, becaplermin, canstatin, angiostatin, endostatin, retinoids, tumistatin, vasculostatin, angioarrestin, vasostatin, bevacizumab, prinomastat, metformin, candesartan, diovan, diltiazem, atenolol, adalat, ranolazine, isosorbide dinitrate, rapamycin, everolimus, ABT 578 (Zotarolimus), AP23573 (Ridaforolimus, formerly known as deforolimus), CCI-779 (Temsirolimus), deuterated rapamycin, tacrolimus, cyclosporine, myriocin, aspirin, diclofenac, indomethacin, sulindac, ketoprofen, flurbiprofen, ibuprofen, naproxen, piroxicam, tenoxicam, tolmetin, ketorolac, oxaprosin,

Assignees

• Elixir Medical Corp

Inventors

• Yan John
• Sirhan Motasim
• Cryer Brett
• Bhat Vinayak

Classifications

• B23K26/382

  by boring · CPC title

• A61F2/07

  Stent-grafts · CPC title

• B23K26/355

  Texturing · CPC title

• B23K26/40

  taking account of the properties of the material involved · CPC title

• A61F2/06

  Blood vessels · CPC title