Systems, devices, and methods for flow control and sample monitoring control

Patent metadata

Field	Value
Publication number	US-10345216-B2
Application number	US-201515504727-A
Country	US
Kind code	B2
Filing date	Aug 20, 2015
Priority date	Aug 20, 2014
Publication date	Jul 9, 2019
Grant date	Jul 9, 2019

Abstract

Sample monitoring and flow control systems and methods are disclosed for monitoring of airborne particulates. A system may include a particle collection filter. The system also includes a fluid moving device for moving a sample through the particle collection filter. Further, the system includes a light source configured to direct irradiating light towards the particle collection filter. The system also includes a light detector positioned to receive the irradiating light passing through the particle collection filter and configured to generate a signal representative of an amount of the received light. Further, the system includes a controller configured to receive the signal and to control the fluid moving device based on the amount of the received light.

First claim

What is claimed is:

1. A sample monitoring control system comprising:
a housing comprising a sample inlet and sample outlet, and enclosing a sample chamber;
a particle collection filter positioned in the sample chamber and configured to collect particles of a sample for analysis;
a fluid moving device for moving the sample through the particle collection filter;
a light source configured to direct irradiating light towards the particle collection filter;
a light detector comprising a photo-responsive material configured to receive measurement light emitted from particles of the sample, wherein the photo-responsive material is flexible and conformally disposed on an inside surface or an outside surface of the housing;
another light detector positioned to receive the irradiating light passing through the particle collection filter and configured to generate a signal representative of an amount of the received light; and
a controller configured to receive the signal and to control the fluid moving device based on the amount of the received light, wherein the control of the fluid moving device comprises a control selected from the group consisting of:
the controller is configured to control the fluid moving device to increase an output of the fluid moving device in response to a decrease in the amount of the received light;
the controller is configured to control the fluid moving device to decrease an output of the fluid moving device in response to an increase in the amount of the received light; and
both of the foregoing.

2. The sample monitoring control system of claim 1 , wherein the particle collection filter comprises a nanofiber filter.

3. The sample monitoring control system of claim 1 , wherein the particle collection filter comprises a plurality of fibers.

4. The sample monitoring control system of claim 3 , wherein the fibers are formed into a fiber mat and configured to collect particles thereon.

5. The sample monitoring control system of claim 3 , wherein the fibers have an average fiber diameter of less than 500 nanometers.

6. The sample monitoring control system of claim 1 , wherein the fluid moving device and the another light detector are positioned within the sample chamber, and
wherein the particle collection filter is positioned between the light detector and the light source.

7. The sample monitoring control system of claim 1 , wherein the light source is configured to emit the irradiating light in a wavelength range effective for inducing autofluorescence in one or more types of bioparticles.

8. The sample monitoring control system of claim 1 , wherein the light source comprises a light emitting diode (LED).

9. The sample monitoring control system of claim 1 , wherein the controller has a configuration selected from the group consisting of:
the controller comprises a plurality of resistors and a voltage regulator; and
the controller comprises a microcontroller.

10. The sample monitoring control system of claim 1 , further comprising a data acquisition device configured to measure a response of the photo-responsive material selected from the group consisting of: a voltage response; a current response; a resistance response; or a combination of two or more of the foregoing.

11. The sample monitoring control system of claim 1 , wherein the particle collection filter has a configuration selected from the group consisting of:
the particle collection filter has a transmittance of at least 30%;
the particle collection filter has a transmittance of at least 50%;
the particle collection filter has a filtration efficiency of at least 85%;
the particle collection filter has a filtration efficiency of greater than 90%;
the particle collection filter is configured to provide a pressure drop not more than 600 Pa; and
the particle collection filter is configured to provide a pressure drop not more than 150 Pa.

12. The sample monitoring control system of claim 1 , wherein the controller is configured to control the fluid moving device based on the amount of the irradiating light received by the another light detector to maintain movement of the sample at a constant or near constant flow rate.

Assignees

• Res Triangle Inst

Inventors

• Clayton Anthony Clint
• Walls Howard Jerome
• Ensor David S
• Khlystov Andrei Yurievich

Classifications

• G01N15/06 Primary

  Investigating concentration of particle suspensions (by weighing G01N5/00; investigating sedimentation of particle suspensions G01N15/04; investigating individual particles G01N15/10) · CPC title

• G01N21/6404

  Atomic fluorescence · CPC title

• G01N2015/1493

  Particle size · CPC title

• G01N15/1459 Primary

  the analysis being performed on a sample stream · CPC title

• G01N21/51

  inside a container, e.g. in an ampoule (G01N21/53 takes precedence) · CPC title