Creatine oral supplementation using creatine hydrochloride salt

Patent metadata

Field	Value
Publication number	US-10342771-B2
Application number	US-201815968858-A
Country	US
Kind code	B2
Filing date	May 2, 2018
Priority date	May 15, 2003
Publication date	Jul 9, 2019
Grant date	Jul 9, 2019

Abstract

The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.

First claim

What is claimed is:

1. A nutritional supplement comprising:
a granular precipitate comprising creatine hydrochloride, wherein the granular precipitate has an aqueous solubility of at least about 150 mg/mL in water at 25° C. after a time period of about 1.5 hours.

2. The nutritional supplement of claim 1 , wherein the granular precipitate comprises at least 95 percent creatine hydrochloride by weight of the granular precipitate.

3. The nutritional supplement of claim 1 , wherein the granular precipitate has an aqueous solubility of at least 600 mg/mL in water at 25° C. after a time period of about 1.5hours.

4. The nutritional supplement of claim 1 , comprised in a powder.

5. The nutritional supplement of claim 1 , comprised in an additive or feed supplement for livestock.

6. The nutritional supplement of claim 1 , comprised in an oral dosage form.

7. A nutritional supplement comprising:
a granular precipitate comprising creatine hydrochloride, wherein the granular precipitate has an aqueous solubility in water of at least an order of magnitude greater than creatine monohydrate.

8. The nutritional supplement of claim 7 , further comprising at least one additive comprising one or more proteins, amino acid supplements, carbohydrates, D-Ribose, fats, fiber, sweeteners, flavoring agents, or combinations thereof.

9. The nutritional supplement of claim 7 , wherein the granular precipitate comprises at least about 95 percent creatine hydrochloride by weight of the granular precipitate.

10. The nutritional supplement of claim 7 , comprised in an oral dosage form.

11. The nutritional supplement of claim 10 , wherein the oral dosage form is a powder.

12. The nutritional supplement of claim 10 , wherein the oral dosage form is a pill, capsule, tablet, or liquid.

13. The nutritional supplement of claim 8 , wherein the at least one additive is a sweetener selected from the group consisting of sucralose, aspartame, saccharin, acesulfame potassium, neohesperidin dihydrochalcone, glycyrrhizin, thaumatin, alitame, stevioside, and combinations thereof.

14. The nutritional supplement of claim 13 , further comprising a flavoring agent selected from the group consisting of cocoa, yogurt, peanut butter, mint, cheesecake, hazelnut paste, almonds, granola, coconut, strawberry, banana, cherry, plum, raspberry, lemon, orange, lime, pineapple, blueberry and other fruit flavors, coffee, cremes, jellies, and combinations thereof.

15. A nutritional supplement comprising:
a granular precipitate comprising creatine hydrochloride, wherein the granular precipitate has an aqueous solubility of at least about 150 mg/mL in water at 25° C. after a time period of about 1.5 hours; and
at least one additive comprising one or more proteins, amino acid supplements, carbohydrates, D-Ribose, fats, fiber, sweeteners, flavoring agents, or combinations thereof.

16. The nutritional supplement of claim 15 , wherein the granular precipitate comprises at least 95 percent creatine hydrochloride by weight of the granular precipitate.

17. The nutritional supplement of claim 15 , comprised in a pill, tablet, capsule, or liquid.

18. The nutritional supplement of claim 15 , comprised in a powder.

19. The nutritional supplement of claim 15 , wherein the granular precipitate has an aqueous solubility of at least 600 mg/mL in water at 25° C. after a time period of about 1.5 hours.

20. A nutritional supplement comprising:
a first granular precipitate comprising creatine hydrochloride, wherein the granular precipitate has an aqueous solubility of at least about 150 mg/mL in water at 25° C. after a time period of about 1.5 hours; and
a creatine selected from the group consisting of creatine ester, creatine pyruvate, creatine phosphate, creatine alpha-ketoglutarate, creatine citrate, and combinations thereof.

21. The nutritional supplement of claim 20 , further comprising HMB, L-glutamine, ribose, or a combination thereof.

22. The nutritional supplement of claim 20 , further comprising a flavoring agent.

Assignees

• Vireo Systems Inc
• Univ Nebraska

Inventors

• Miller Donald W
• Vennerstrom Jonathan L
• Faulkner Mark C

Classifications

• A61P21/06

  Anabolic agents (androgens A61P5/26) · CPC title

• A23K20/10

  Organic substances · CPC title

• A23K50/10

  for ruminants · CPC title

• A23K20/142

  Amino acids; Derivatives thereof · CPC title

• A61K31/661

  Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion {or mevinphos} · CPC title