Creatine oral supplementation using creatine hydrochloride salt

Patent metadata

Field	Value
Publication number	US-9962352-B2
Application number	US-201615344835-A
Country	US
Kind code	B2
Filing date	Nov 7, 2016
Priority date	May 15, 2003
Publication date	May 8, 2018
Grant date	May 8, 2018

Abstract

The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.

First claim

What is claimed is:

1. An oral supplement comprising:
creatine HCl having an aqueous solubility of at least about 15 times greater than creatine monohydrate in water at 25° C. after a time period of about 1.5 hours.

2. The oral supplement of claim 1 , comprised in a beverage, a liquid meal replacement, a nutritional bar, or a food product.

3. The oral supplement of claim 1 , comprised in an additive or feed supplement for livestock.

4. The oral supplement of claim 1 , further comprising:
at least one flavoring agent selected from the group comprising cocoa, yogurt, peanut butter, mint, cheesecake, hazelnut paste, almonds, granola, coconut, strawberry, banana, cherry, plum, raspberry, lemon, orange, lime, pineapple, blueberry and other fruit flavors, coffee, or cremes and jellies, and combinations thereof.

5. The oral supplement of claim 1 , further comprising:
at least one additional supplement selected from the group comprising carbonate salt, methylsulfonylmethane, glucosamine, and chondroitin.

6. The oral supplement of claim 1 , further comprising:
at least one compound selected from the group comprising proteins, amino acid supplements, carbohydrates, D-Ribose, fats, fiber and combinations thereof.

7. An oral supplement comprising:
creatine HCl having a solubility of at least about 150 mg/mL in water at 25° C. after a time period of about 1.5 hours.

8. The oral supplement of claim 7 , wherein the creatine HCl is at least 95 percent free of contaminants.

9. The oral supplement of claim 7 , comprising greater than about 50 percent of creatine HCl.

10. The oral supplement of claim 7 , comprised in a liquid or feed additive.

11. The oral supplement of claim 7 , comprised in a pill, capsule, tablet, or liquid.

12. A supplement comprising granules for consumption by an animal, wherein the granules comprise creatine HCl, wherein the creatine HCl has an aqueous solubility of at least an order of magnitude higher than the aqueous solubility of creatine monohydrate.

13. The supplement of claim 12 , further comprising at least one additional supplement selected from the group comprising carbonate salts, methylsulfonylmethane, glucosamine, and chondroitin.

14. The supplement of claim 12 , further comprising at least one compound selected from the group comprising proteins, amino acid supplements, carbohydrates, D-Ribose, fats, fiber and combinations thereof.

15. The supplement of claim 12 , further comprising at least one flavoring agent.

16. The supplement of claim 12 , comprised in an additive or feed supplement for livestock.

17. The supplement of claim 12 , comprised in a beverage, a liquid meal replacement, a nutritional bar, or a food product.

18. The supplement of claim 12 , wherein the creatine HCl has an aqueous solubility of at least 600 mg/ml in water at 25° C. after a time period of about 1.5 hours.

19. The supplement of claim 12 , wherein the granules consist essentially of creatine HCl.

20. The supplement of claim 12 , wherein the granules are at least 95 percent free of contaminants.

Assignees

• Vireo Systems Inc
• Univ Nebraska

Inventors

• Miller Donald W
• Vennerstrom Jonathan L
• Faulkner Mark C

Classifications

• A61P21/06

  Anabolic agents (androgens A61P5/26) · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23K20/10

  Organic substances · CPC title

• A23L33/175

  Amino acids · CPC title

• A61K31/198 Primary

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title