Oral biofilm inhibitor

Patent metadata

Field	Value
Publication number	US-10307342-B2
Application number	US-201515505411-A
Country	US
Kind code	B2
Filing date	Aug 21, 2015
Priority date	Aug 22, 2014
Publication date	Jun 4, 2019
Grant date	Jun 4, 2019

Abstract

There is provided an oral biofilm inhibitor having an exceptional inhibitory effect on oral biofilm formation. It is an oral biofilm inhibitor comprising a curable composition containing an antimicrobial agent, wherein a compressive strength of a cured product formed by curing the composition is 150 MPa or less, and a content of the antimicrobial agent is 0.001 to 3% by weight. An oral biofilm inhibitor thus obtained is used for inhibiting biofilm formation in an oral cavity by applying a curable composition containing an antimicrobial agent to a dental defect site for allowing the composition to cure at the dental defect site, and then disintegrating the cured composition.

First claim

The invention claimed is:

1. An oral biofilm inhibitor consisting of a curable composition containing cetylpyridinium chloride in paste form and which is at least one of a hydraulic composition, a photocurable composition or a thermosetting composition, wherein a compressive strength of a cured product formed by curing the composition is 10 MPa or less, and a content of the cetylpyridinium chloride is 0.001 to 3% by weight.

2. The oral biofilm inhibitor according to claim 1 , used for inhibiting biofilm formation in an oral cavity by applying the curable composition containing the cetylpyridinium chloride to a dental defect site for allowing the composition to cure at the dental defect site, and then disintegrating the cured composition.

3. The oral biofilm inhibitor according to claim 2 , wherein the curable composition is again applied to the site where the cured composition has been disintegrated.

4. An oral biofilm inhibitor kit comprising a curable composition and cetylpyridinium chloride in paste form and which is at least one of a hydraulic composition, a photocurable composition or a thermosetting composition, wherein
a compressive strength of a cured product formed by curing an oral biofilm inhibitor is 10 MPa or less, and
the curable composition and the cetylpyridinium chloride are blended for use such that a content of the cetylpyridinium chloride in the oral biofilm inhibitor comes to be 0.001 to 3% by weight.

5. An oral biofilm inhibitor kit comprising a curable composition in paste form which is at least one of a hydraulic composition, a photocurable composition or a thermosetting composition and a liquid agent containing water as a main component, wherein
at least one of the curable composition and the liquid agent containing water as a main component comprises the cetylpyridinium chloride,
a compressive strength of a cured product formed by curing the oral biofilm inhibitor is 10 MPa or less, and
the curable composition and the liquid agent are blended for use such that a content of the cetylpyridinium chloride comes to be 0.001 to 3% by weight.

6. A method for producing an oral biofilm inhibitor comprising a curable composition containing cetylpyridinium chloride according to claim 1 , comprising blending the curable composition and the cetylpyridinium chloride such that a content of the cetylpyridinium chloride in the oral biofilm inhibitor comes to be 0.001 to 3% by weight.

7. A method for producing an oral biofilm inhibitor comprising a curable composition containing cetylpyridinium chloride according to claim 2 , comprising blending the curable composition and the cetylpyridinium chloride such that a content of the cetylpyridinium chloride in the oral biofilm inhibitor comes to be 0.001 to 3% by weight.

8. A method for producing an oral biofilm inhibitor comprising a curable composition containing cetylpyridinium chloride according to claim 3 , comprising blending the curable composition and the cetylpyridinium chloride such that a content of the cetylpyridinium chloride in the oral biofilm inhibitor comes to be 0.001 to 3% by weight.

Assignees

• Nat Univ Corporation Okayama Univ

Inventors

• Omori Kazuhiro
• Ito Takashi
• Takashiba Shogo
• Irie Masao

Classifications

• A61P31/04

  Antibacterial agents · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K6/20

  Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish · CPC title

• A61K6/884

  comprising natural or synthetic resins · CPC title

• A61K6/80 Primary

  Preparations for artificial teeth, for filling teeth or for capping teeth · CPC title