Needle-shaped body and method for producing needle-shaped body

Patent metadata

Field	Value
Publication number	US-10300261-B2
Application number	US-201715842085-A
Country	US
Kind code	B2
Filing date	Dec 14, 2017
Priority date	Jun 23, 2015
Publication date	May 28, 2019
Grant date	May 28, 2019

Abstract

A method for producing a needle-shaped body having needles on a first surface of a substrate made of a thermoplastic resin, the method including the steps of: forming the needle-shaped body by filling the thermoplastic resin into a duplication plate having recesses that correspond to shapes of the needles; providing a support member made of a material different from a material for the needle-shaped body on a second surface of the substrate which is opposite to the first surface; and removing the needle-shaped body and the support member which are integrally formed from the duplication plate.

First claim

What is claimed is:

1. A method for producing a needle-shaped body, the method comprising the steps of:
filling a melted thermoplastic resin into a duplication plate having recesses having inverted needle shapes;
applying a support member to a surface of the thermoplastic resin, which is opposite to a surface of the thermoplastic resin facing the duplication plate, wherein the support member is made of a material different from the thermoplastic resin of;
removing the thermoplastic resin and the support member, which are integrally formed on the duplication plate, from the duplication plate; and
removing the support member from the thermoplastic resin using a solvent in which the material for the support member is soluble, wherein the removed thermoplastic resin forms a needle-shaped body comprising a substrate having a first surface having needles.

2. The method for producing a needle-shaped body of claim 1 , wherein the support member is made of a water-soluble material.

3. The method for producing a needle-shaped body of claim 1 , wherein the support member is made of polyvinyl alcohol.

4. The method for producing a needle-shaped body of claim 1 , wherein a surface of the support member that is in contact with the thermoplastic resin has a recess, a projection or a configuration made by combination thereof.

5. The method for producing a needle-shaped body of claim 1 , further comprising a step of adhering, after the support member has been removed, the surface of the thermoplastic resin that faced the support member, to a convex curved surface of a reinforcement layer.

6. A method for producing a needle-shaped body having needles on a first surface of a substrate made of a thermoplastic resin, the method comprising the steps of:
forming the needle-shaped body by filling the thermoplastic resin into a duplication plate having recesses that correspond to shapes of the needles;
providing a support member made of a material different from a material for the needle-shaped body on a second surface of the substrate which is opposite to the first surface;
removing the needle-shaped body and the support member which are integrally formed from the duplication plate;
removing the support member from the needle-shaped body; and
adhering the second surface of the substrate, with the support member removed, to a convex curved surface of a reinforcement layer.

7. The method for producing a needle-shaped body of claim 6 , wherein the support member is made of a water-soluble material.

8. The method for producing a needle-shaped body of claim 6 , wherein the support member is made of polyvinyl alcohol.

9. The method for producing a needle-shaped body of claim 6 , wherein a surface of the support member that is in contact with the second surface of the substrate has a recess, a projection or a configuration made by combination thereof.

10. A method for producing a needle-shaped body, the method comprising the steps of:
filling a melted thermoplastic resin into a duplication plate having recesses having inverted needle shapes;
applying a support member to a surface of the thermoplastic resin, which is opposite to a surface of the thermoplastic resin facing the duplication plate, wherein the support member is made of a material different from the thermoplastic resin;
removing the thermoplastic resin and the support member, which are integrally formed on the duplication plate, from the duplication plate; and
removing the support member from the thermoplastic resin, wherein the removed thermoplastic resin forms a needle-shaped body comprising a substrate having a first surface having needles,
wherein the step of applying the support member is a step of adhering the support member to the thermoplastic resin by using an adhesive having adhesiveness that varies in response to external stimulation or wherein the material of the support member has adhesiveness that varies in response to external stimulation to the thermoplastic material and
the step of removing the support member from the thermoplastic material comprises applying the external stimulation.

11. The method for producing a needle-shaped body of claim 10 , wherein the support member is made of a water-soluble material.

12. The method for producing a needle-shaped body of claim 10 , wherein the support member is made of polyvinyl alcohol.

13. The method for producing a needle-shaped body of claim 10 , wherein the external stimulation is ultraviolet light, electron beam, infrared light or heat.

14. The method for producing a needle-shaped body of claim 10 , wherein a surface of the support member that is in contact with the thermoplastic resin has a recess, a projection or a configuration made by combination thereof.

Assignees

• Toppan Printing Co Ltd

Inventors

• Shiomitsu Kazuhiko

Classifications

• B81C1/00

  Manufacture or treatment of devices or systems in or on a substrate (B81C3/00 takes precedence) · CPC title

• B29C45/14336

  Coating a portion of the article, e.g. the edge of the article (B29C45/14573 and B29C45/14598 take precedence) · CPC title

• A61M37/0015 Primary

  by using microneedles · CPC title

• B29C65/4835

  Heat curing adhesives · CPC title

• A61M2037/0046

  Solid microneedles · CPC title