Active ingredient capsules

Patent metadata

Field	Value
Publication number	US-10299996-B2
Application number	US-201415030521-A
Country	US
Kind code	B2
Filing date	Oct 18, 2014
Priority date	Oct 22, 2013
Publication date	May 28, 2019
Grant date	May 28, 2019

Abstract

Active ingredient capsules are proposed which are obtainable by, with the input of mechanical and thermal energy, (a) dissolving and/or dispersing proteins, polysaccharides and cellulose derivatives in water, (b) adding the active ingredients to be encapsulated, (c) hardening the resulting coacervates with the addition of tannins and optionally (d) then subjecting them to a spray drying.

First claim

What is claimed is:

1. A process for producing controlled release active ingredient capsules, consisting essentially of:
(a) dissolving and/or dispersing (a1) proteins, (a2) polysaccharides and (a3) cellulose derivatives in water with the input of mechanical and thermal energy to form a coacervate,
(b) adding active ingredients to be encapsulated to the coacervate to form active ingredient capsules,
(c) hardening the resulting active ingredient capsules with the addition of natural tannins, in the absence of glutaric aldehyde and formaldehyde for a period of 5 to 10 hours, and
(d) optionally, spray-drying the hardened active ingredient capsules and wherein the process occurs in a maximum of 12 hours;
wherein the process is conducted with half of the water that would be required if cellulose derivatives (a3) were not used in the process.

2. The process according to claim 1 , wherein the proteins (a1) used are gelatines which have a gel strength of from 100 to 300 Bloom.

3. The process according to claim 1 , wherein the polysaccharides (a2) are selected from the group consisting of pectins, xanthans, gum arabic, agaroses, and mixtures thereof.

4. The process according to claim 1 , wherein the cellulose derivatives (a3) are cellulose ethers or cellulose esters which have a degree of substitution above 80%.

5. The process according to claim 1 , wherein the active ingredients are aromas or perfume oils.

6. The process according to claim 1 , wherein the components a1, a2 and a3 are used in the weight ratio of a1:a2:a3, wherein a1 is about 10, a2 is about 1 to 5, and a3 is about 0.5 to 2.

7. The process according to claim 1 , wherein the components a1+a2+a3 to the active ingredients to be encapsulated are used in the weight ratio of about 5 to 15:1.

8. The process according to claim 1 , wherein step (a) is carried out at temperatures in the range from about 20 to about 90° C.

9. The process according to claim 1 , wherein, the, natural tannins are added in an amount of from about 0.1 to about 2% by weight based on the weight of the active ingredient capsules formed in step (b).

10. The process according to claim 1 , wherein the hardened capsules are spray-dried in the presence of polysaccharides.

11. The process of claim 1 wherein active ingredient capsule produced therefrom has a breaking strength equivalent to a process that employs a formaldehyde or glutaraldehyde crosslinker.

12. The process of claim 1 wherein the active ingredient capsules produced therefrom have a D50 value of from 50 μm to about 100 μm.

Assignees

• Symrise Ag

Inventors

• Weissbrodt Jenny
• Aickele Frank
• Bertram Ralf

Classifications

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61K8/73

  Polysaccharides · CPC title

• A61K2800/56

  Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms · CPC title

• A61K9/5036

  Polysaccharides, e.g. gums, alginate; Cyclodextrin · CPC title

• A61K8/9717

  Rhodophycota or Rhodophyta [red algae], e.g. Porphyra · CPC title