Bone cement and methods of use thereof

Patent metadata

Field	Value
Publication number	US-10272174-B2
Application number	US-201715491214-A
Country	US
Kind code	B2
Filing date	Apr 19, 2017
Priority date	Sep 14, 2006
Publication date	Apr 30, 2019
Grant date	Apr 30, 2019

Abstract

A bone cement comprising an acrylic polymer mixture which is formulated to have a relatively high viscosity for a relatively long window, due to distributions of molecular weights and/or sizes of acrylic beads.

First claim

The invention claimed is:

1. A bone cement comprising an acrylic polymer mixture, the cement characterized in that it achieves a viscosity of at least 500 Pascal-second within 180 seconds following initiation of mixing of a monomer component and a polymer component and characterized by sufficient biocompatibility to permit in-vivo use;
wherein the mixture includes PMMA;
wherein the PMMA is provided as a population of beads divided into at least three sub-populations, each sub-population characterized by an average bead diameter.

2. A bone cement according to claim 1 , wherein the viscosity of the mixture remains between 500 and 2000 Pascal-second for a working window of at least 5 minutes after the initial period.

3. A bone cement according to claim 2 , wherein the working window is at least 8 minutes long.

4. A bone cement according to claim 1 , wherein the mixture includes Barium Sulfate.

5. A bone cement according to claim 1 , wherein the PMMA is provided as a PMMA/styrene copolymer.

6. A bone cement according to claim 1 , wherein the PMMA is provided as a population of beads divided into at least two sub-populations, each sub-population characterized by an average molecular weight.

7. A bone cement according to claim 6 , wherein a largest sub-population of PMMA beads is characterized by an MW of 150,000 Dalton to 300,000 Dalton.

8. A bone cement according to claim 6 , wherein a largest sub-population of PMMA beads includes 90-98% (w/w) of the beads.

9. A bone cement according to claim 6 , wherein a high molecular weight sub-population of PMMA beads is characterized by an average MW of at least 3,000,000 Dalton.

10. A bone cement according to claim 6 , wherein a high molecular weight sub-population of PMMA beads includes 2 to 3% (w/w) of the beads.

11. A bone cement according to claim 6 , wherein a low molecular weight sub-population of PMMA beads is characterized by an average MW of less than 15,000 Dalton.

12. A bone cement according to claim 6 , wherein a low molecular weight sub-population of PMMA beads includes 0.75 to 1.5% (W/W) of the beads.

13. A bone cement according to claim 1 , wherein at least one bead sub-population of characterized by an average diameter is further divided into at least two sub-sub-populations, each sub-sub-population characterized by an average molecular weight.

14. A bone cement according to claim 1 , further comprising processed bone and/or synthetic bone.

15. A bone cement according to claim 1 , characterized in that the cement achieves a viscosity of at least 500 Pascal-second when 100% of a polymer component is wetted by a monomer component.

16. A bone cement according to claim 1 , wherein the viscosity is at least 800 Pascal-second.

17. A bone cement according to claim 1 , wherein the viscosity is at least 1500 Pascal-second.

Assignees

• Depuy Synthes Products Inc

Inventors

• Beyar Mordechay
• Globerman Oren

Classifications

• A61K6/15

  Compositions characterised by their physical properties · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L24/06 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title

• A61L24/0005

  Ingredients of undetermined constitution or reaction products thereof · CPC title