Bone cement and methods of use thereof

Patent metadata

Field	Value
Publication number	US-9642932-B2
Application number	US-37789407-A
Country	US
Kind code	B2
Filing date	Sep 11, 2007
Priority date	Sep 14, 2006
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

A bone cement comprising an acrylic polymer mixture which is formulated to have a relatively high viscosity for a relatively long window, due to distributions of molecular weights and/or sizes of acrylic beads.

First claim

The invention claimed is:

1. A cement kit, comprising:
(a) a liquid component including a monomer; and
(b) a powder component including polymeric beads,
in which the distribution of the molecular weight of the powder component is non-normal so that it is skewed to a higher molecular weight by introduction of higher molecular weight beads, the non-normal distribution of the molecular weight of the powder component causing (a) an increase in the immediate viscosity of a mixture of the liquid and powder components and compared with a cement having a substantially normal distribution, and (b) an increase in the length of the working window period in which the viscosity of the cement does not exceed 500 Pa.s compared with a cement having a substantially normal distribution.

2. A cement kit according to claim 1 , in which the higher molecular weight beads have an average molecular weight of at least a factor of 2 of an average molecular weight of the polymeric beads.

3. A cement kit according to claim 2 , in which the factor is at least 3.

4. A cement kit according to claim 3 , in which the factor is at least 5.

5. A cement kit according to claim 1 , further comprising a relatively small component including smaller sized beads.

6. A cement kit according to claim 1 , wherein the polymeric beads comprise PMMA.

7. A cement kit according to claim 1 , wherein the higher molecular weight beads have a molecular weight of about 600,000 Dalton to about 5,000,000 Dalton.

8. A cement kit according to claim 1 , wherein the higher molecular weight beads have a molecular weight of about 3,000,000 to 4,000,000 Dalton.

9. A cement kit according to claim 1 , wherein the higher molecular weight beads have a molecular weight of about 3,500,000 to 3,900,000 Dalton.

10. A cement kit according to claim 1 , wherein an average molecular weight of the polymeric beads is about 130,000 to 170,000 Dalton.

11. A cement kit according to claim 1 , wherein an average molecular weight of the polymeric beads is about 375,000 Dalton.

Assignees

• Beyar Mordechay
• Globerman Oren
• Depuy Synthes Products Inc

Inventors

• Beyar Mordechay
• Globerman Oren

Classifications

• A61K6/15

  Compositions characterised by their physical properties · CPC title

• A61L24/06 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title

• A61L24/046 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (A61L24/043 takes precedence) · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L24/02

  containing inorganic materials · CPC title